| Bellevue Group AG |
9942313 |
16.0% |
| ARMISTICE CAPITAL, LLC |
6000000 |
9.7% |
| BlackRock Finance, Inc. |
5401728 |
8.7% |
| BlackRock, Inc. |
5057175 |
8.2% |
| VANGUARD GROUP INC |
4135319 |
6.7% |
| MILLENNIUM MANAGEMENT LLC |
3312672 |
5.3% |
| Frazier Life Sciences Management, L.P. |
3010727 |
4.9% |
| RA CAPITAL MANAGEMENT, L.P. |
2082021 |
3.4% |
| STATE STREET CORP |
1542590 |
2.5% |
| GEODE CAPITAL MANAGEMENT, LLC |
1415239 |
2.3% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1337020 |
2.2% |
| TWO SIGMA INVESTMENTS, LP |
1223993 |
2.0% |
| TWO SIGMA ADVISERS, LP |
1151400 |
1.9% |
| Rock Springs Capital Management LP |
1053647 |
1.7% |
| Hudson Bay Capital Management LP |
916527 |
1.5% |
| DIMENSIONAL FUND ADVISORS LP |
898497 |
1.5% |
| PANAGORA ASSET MANAGEMENT INC |
741490 |
1.2% |
| NORTHERN TRUST CORP |
712168 |
1.1% |
| MARSHALL WACE, LLP |
658007 |
1.1% |
| PINNACLE ASSOCIATES LTD |
637319 |
1.0% |
| ACADIAN ASSET MANAGEMENT LLC |
586079 |
0.9% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
510505 |
0.8% |
| JANE STREET GROUP, LLC |
487201 |
0.8% |
| RENAISSANCE TECHNOLOGIES LLC |
484027 |
0.8% |
| JPMORGAN CHASE & CO |
480261 |
0.8% |
| GOLDMAN SACHS GROUP INC |
476526 |
0.8% |
| Connor, Clark & Lunn Investment Management Ltd. |
475056 |
0.8% |
| MORGAN STANLEY |
472237 |
0.8% |
| MACQUARIE GROUP LTD |
420000 |
0.7% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
418890 |
0.7% |
| SILVERARC CAPITAL MANAGEMENT, LLC |
370000 |
0.6% |
| Woodline Partners LP |
369542 |
0.6% |
| PRINCIPAL FINANCIAL GROUP INC |
348421 |
0.6% |
| FEDERATED HERMES, INC. |
300499 |
0.5% |
| WELLINGTON MANAGEMENT GROUP LLP |
265407 |
0.4% |
| Bank of New York Mellon Corp |
261944 |
0.4% |
| TANG CAPITAL MANAGEMENT LLC |
218856 |
0.4% |
| Walleye Capital LLC |
203945 |
0.3% |
| Ikarian Capital, LLC |
200079 |
0.3% |
| Nuveen Asset Management, LLC |
198470 |
0.3% |
| TD ASSET MANAGEMENT INC |
169000 |
0.3% |
| Ghost Tree Capital, LLC |
150000 |
0.2% |
| HealthInvest Partners AB |
143407 |
0.2% |
| AQR CAPITAL MANAGEMENT LLC |
143161 |
0.2% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
129996 |
0.2% |
| Schonfeld Strategic Advisors LLC |
122782 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
122032 |
0.2% |
| BANK OF AMERICA CORP /DE/ |
119759 |
0.2% |
| D. E. Shaw & Co., Inc. |
114060 |
0.2% |
| PDT Partners, LLC |
110751 |
0.2% |
| FRANKLIN RESOURCES INC |
108131 |
0.2% |
| ALLIANCEBERNSTEIN L.P. |
102730 |
0.2% |
| STATE OF WISCONSIN INVESTMENT BOARD |
95698 |
0.2% |
| GSA CAPITAL PARTNERS LLP |
95689 |
0.2% |
| BNP PARIBAS FINANCIAL MARKETS |
92859 |
0.1% |
| Swiss National Bank |
91800 |
0.1% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
91327 |
0.1% |
| RHUMBLINE ADVISERS |
88294 |
0.1% |
| UBS Group AG |
85541 |
0.1% |
| AMERIPRISE FINANCIAL INC |
79458 |
0.1% |
| Atom Investors LP |
78005 |
0.1% |
| HRT FINANCIAL LP |
75042 |
0.1% |
| STRS OHIO |
67900 |
0.1% |
| Parallax Volatility Advisers, L.P. |
66617 |
0.1% |
| BOOTHBAY FUND MANAGEMENT, LLC |
58763 |
0.1% |
| Legal & General Group Plc |
56103 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47123 |
0.1% |
| BARCLAYS PLC |
45114 |
0.1% |
| Pennant Investors, LP |
43800 |
0.1% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
41742 |
0.1% |
| Invesco Ltd. |
35681 |
0.1% |
| MetLife Investment Management, LLC |
35551 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
34979 |
0.1% |
| Caption Management, LLC |
34400 |
0.1% |
| DEUTSCHE BANK AG\ |
33564 |
0.1% |
| STIFEL FINANCIAL CORP |
33310 |
0.1% |
| JANUS HENDERSON GROUP PLC |
33100 |
0.1% |
| LPL Financial LLC |
30458 |
49.2‰ |
| SIMPLEX TRADING, LLC |
28657 |
46.3‰ |
| Jefferies Financial Group Inc. |
25000 |
40.3‰ |
| CITIGROUP INC |
24635 |
39.8‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
23444 |
37.8‰ |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
23400 |
37.8‰ |
| Brevan Howard Capital Management LP |
21522 |
34.7‰ |
| VOYA INVESTMENT MANAGEMENT LLC |
21323 |
34.4‰ |
| WELLS FARGO & COMPANY/MN |
20976 |
33.9‰ |
| Virtus ETF Advisers LLC |
19343 |
31.2‰ |
| CITADEL ADVISORS LLC |
18569 |
30.0‰ |
| Russell Investments Group, Ltd. |
18390 |
29.7‰ |
| Diversified Trust Co |
18097 |
29.2‰ |
| Evercore Wealth Management, LLC |
17543 |
28.3‰ |
| Tower Research Capital LLC (TRC) |
17344 |
28.0‰ |
| Zurcher Kantonalbank (Zurich Cantonalbank) |
16072 |
25.9‰ |
| CORNERCAP INVESTMENT COUNSEL INC |
16025 |
25.9‰ |
| K2 PRINCIPAL FUND, L.P. |
14800 |
23.9‰ |
| PRELUDE CAPITAL MANAGEMENT, LLC |
14334 |
23.1‰ |
| EXCHANGE TRADED CONCEPTS, LLC |
13532 |
21.8‰ |
| Arizona State Retirement System |
13134 |
21.2‰ |
| DRW Securities, LLC |
13105 |
21.2‰ |
| HSBC HOLDINGS PLC |
12103 |
19.5‰ |
