| RTW INVESTMENTS, LP |
17687772 |
22.2% |
| WELLINGTON MANAGEMENT GROUP LLP |
9155720 |
11.5% |
| BlackRock, Inc. |
7097287 |
8.9% |
| BlackRock Finance, Inc. |
6192627 |
7.8% |
| VANGUARD GROUP INC |
5808550 |
7.3% |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
4327922 |
5.4% |
| MAVERICK CAPITAL LTD |
3928312 |
4.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
3169448 |
4.0% |
| JANUS HENDERSON GROUP PLC |
2919078 |
3.7% |
| CITADEL ADVISORS LLC |
2818069 |
3.5% |
| STATE STREET CORP |
2779866 |
3.5% |
| FRANKLIN RESOURCES INC |
1873689 |
2.3% |
| GEODE CAPITAL MANAGEMENT, LLC |
1603610 |
2.0% |
| Frazier Life Sciences Management, L.P. |
1561230 |
2.0% |
| Boxer Capital, LLC |
1466051 |
1.8% |
| PERCEPTIVE ADVISORS LLC |
1246597 |
1.6% |
| BANK OF AMERICA CORP /DE/ |
1238044 |
1.6% |
| Pictet Asset Management Holding SA |
1226387 |
1.5% |
| Avidity Partners Management LP |
1100000 |
1.4% |
| COWEN AND COMPANY, LLC |
1100000 |
1.4% |
| Novo Holdings A/S |
1100000 |
1.4% |
| BAMCO INC /NY/ |
979331 |
1.2% |
| DIMENSIONAL FUND ADVISORS LP |
946175 |
1.2% |
| EVENTIDE ASSET MANAGEMENT, LLC |
770691 |
1.0% |
| TANG CAPITAL MANAGEMENT LLC |
750000 |
0.9% |
| GOLDMAN SACHS GROUP INC |
695908 |
0.9% |
| COMERICA BANK |
686654 |
0.9% |
| Russell Investments Group, Ltd. |
677744 |
0.8% |
| Siren, L.L.C. |
600000 |
0.8% |
| NORTHERN TRUST CORP |
588597 |
0.7% |
| JPMORGAN CHASE & CO |
579738 |
0.7% |
| FMR LLC |
579279 |
0.7% |
| Woodline Partners LP |
561966 |
0.7% |
| First Turn Management, LLC |
560989 |
0.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
549492 |
0.7% |
| EcoR1 Capital, LLC |
508393 |
0.6% |
| MORGAN STANLEY |
475988 |
0.6% |
| Voss Capital, LP |
421700 |
0.5% |
| UBS Group AG |
405782 |
0.5% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
386996 |
0.5% |
| M28 Capital Management LP |
385680 |
0.5% |
| Invesco Ltd. |
352026 |
0.4% |
| Logos Global Management LP |
350000 |
0.4% |
| WCM INVESTMENT MANAGEMENT, LLC |
292901 |
0.4% |
| STEMPOINT CAPITAL LP |
270983 |
0.3% |
| ALLIANCEBERNSTEIN L.P. |
261347 |
0.3% |
| Privium Fund Management B.V. |
250980 |
0.3% |
| ACUTA CAPITAL PARTNERS, LLC |
250370 |
0.3% |
| Bank of New York Mellon Corp |
239877 |
0.3% |
| EFG Asset Management (North America) Corp. |
222046 |
0.3% |
| ADAR1 Capital Management, LLC |
211400 |
0.3% |
| SPHERA FUNDS MANAGEMENT LTD. |
206933 |
0.3% |
| Hennion & Walsh Asset Management, Inc. |
204110 |
0.3% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
200000 |
0.3% |
| Ikarian Capital, LLC |
197096 |
0.2% |
| GMT CAPITAL CORP |
188100 |
0.2% |
| TD ASSET MANAGEMENT INC |
178164 |
0.2% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
177548 |
0.2% |
| SYNOVUS FINANCIAL CORP |
168090 |
0.2% |
| Nuveen Asset Management, LLC |
167716 |
0.2% |
| Exome Asset Management LLC |
159552 |
0.2% |
| BNP PARIBAS FINANCIAL MARKETS |
158439 |
0.2% |
| New Leaf Venture Partners, L.L.C. |
150706 |
0.2% |
| Neuberger Berman Group LLC |
150578 |
0.2% |
| BLAIR WILLIAM & CO/IL |
142714 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
139613 |
0.2% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
139572 |
0.2% |
| NORDEA INVESTMENT MANAGEMENT AB |
132486 |
0.2% |
| BARCLAYS PLC |
130797 |
0.2% |
| JANE STREET GROUP, LLC |
130538 |
0.2% |
| Swiss National Bank |
124600 |
0.2% |
| Rafferty Asset Management, LLC |
117645 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
105325 |
0.1% |
| NEOS Investment Management LLC |
102847 |
0.1% |
| PRUDENTIAL FINANCIAL INC |
102705 |
0.1% |
| RHUMBLINE ADVISERS |
101134 |
0.1% |
| RENAISSANCE TECHNOLOGIES LLC |
99574 |
0.1% |
| HARBOR CAPITAL ADVISORS, INC. |
97134 |
0.1% |
| DekaBank Deutsche Girozentrale |
89700 |
0.1% |
| Rockefeller Capital Management L.P. |
86973 |
0.1% |
| RICE HALL JAMES & ASSOCIATES, LLC |
75423 |
0.1% |
| THRIVENT FINANCIAL FOR LUTHERANS |
75177 |
0.1% |
| Legal & General Group Plc |
72908 |
0.1% |
| TORRAY INVESTMENT PARTNERS LLC |
67216 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
62120 |
0.1% |
| MACQUARIE GROUP LTD |
58000 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
44745 |
0.1% |
| Erste Asset Management GmbH |
44700 |
0.1% |
| BOOTHBAY FUND MANAGEMENT, LLC |
43236 |
0.1% |
| DEUTSCHE BANK AG\ |
39671 |
49.7‰ |
| Vontobel Holding Ltd. |
38544 |
48.3‰ |
| MetLife Investment Management, LLC |
37501 |
47.0‰ |
| Harbour Capital Advisors, LLC |
36180 |
45.4‰ |
| NORGES BANK |
34752 |
43.6‰ |
| B. Metzler seel. Sohn & Co. AG |
34418 |
43.2‰ |
| CITIGROUP INC |
34090 |
42.7‰ |
| PIER 88 INVESTMENT PARTNERS LLC |
30900 |
38.7‰ |
| JENNISON ASSOCIATES LLC |
30578 |
38.3‰ |
| Rathbones Group PLC |
30000 |
37.6‰ |
| Assenagon Asset Management S.A. |
29986 |
37.6‰ |
