| JANUS HENDERSON GROUP PLC |
2485751 |
13.8% |
| Avoro Capital Advisors LLC |
2055555 |
11.4% |
| BAKER BROS. ADVISORS LP |
1974590 |
10.9% |
| RTW INVESTMENTS, LP |
1915862 |
10.6% |
| PAULSON & CO. INC. |
1850000 |
10.2% |
| VANGUARD GROUP INC |
1806704 |
10.0% |
| BlackRock, Inc. |
1494167 |
8.3% |
| BlackRock Finance, Inc. |
1427250 |
7.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
858765 |
4.8% |
| FMR LLC |
789003 |
4.4% |
| STATE STREET CORP |
744714 |
4.1% |
| GEODE CAPITAL MANAGEMENT, LLC |
399854 |
2.2% |
| Artisan Partners Limited Partnership |
345085 |
1.9% |
| PERCEPTIVE ADVISORS LLC |
264600 |
1.5% |
| Rock Springs Capital Management LP |
245499 |
1.4% |
| BANK OF AMERICA CORP /DE/ |
239554 |
1.3% |
| MORGAN STANLEY |
220031 |
1.2% |
| ArrowMark Colorado Holdings LLC |
187393 |
1.0% |
| UBS Group AG |
173240 |
1.0% |
| GOLDMAN SACHS GROUP INC |
171451 |
0.9% |
| Erste Asset Management GmbH |
164400 |
0.9% |
| ARMISTICE CAPITAL, LLC |
150000 |
0.8% |
| TCG Crossover Management, LLC |
149283 |
0.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
138314 |
0.8% |
| Woodline Partners LP |
138309 |
0.8% |
| Pictet Asset Management Holding SA |
137275 |
0.8% |
| Invesco Ltd. |
133758 |
0.7% |
| NORTHERN TRUST CORP |
131445 |
0.7% |
| Tao Capital Management LP |
130529 |
0.7% |
| Siren, L.L.C. |
125942 |
0.7% |
| Polar Capital Holdings Plc |
125300 |
0.7% |
| NORGES BANK |
116027 |
0.6% |
| Fiera Capital Corp |
115415 |
0.6% |
| AMERICAN CENTURY COMPANIES INC |
111113 |
0.6% |
| Rheos Capital Works Inc. |
110215 |
0.6% |
| Affinity Asset Advisors, LLC |
110000 |
0.6% |
| FRED ALGER MANAGEMENT, LLC |
102455 |
0.6% |
| GROUP ONE TRADING LLC |
100146 |
0.6% |
| EMERALD ADVISERS, LLC |
96764 |
0.5% |
| AlpInvest Partners B.V. |
84595 |
0.5% |
| Connor, Clark & Lunn Investment Management Ltd. |
83062 |
0.5% |
| Mirae Asset Global Investments Co., Ltd. |
82737 |
0.5% |
| Nuveen Asset Management, LLC |
80799 |
0.4% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
75759 |
0.4% |
| EcoR1 Capital, LLC |
75000 |
0.4% |
| Bank of New York Mellon Corp |
73815 |
0.4% |
| MPM BioImpact LLC |
71185 |
0.4% |
| Tri Locum Partners LP |
65352 |
0.4% |
| TD ASSET MANAGEMENT INC |
55730 |
0.3% |
| JPMORGAN CHASE & CO |
52656 |
0.3% |
| NEW YORK STATE COMMON RETIREMENT FUND |
51173 |
0.3% |
| DEUTSCHE BANK AG\ |
46571 |
0.3% |
| University of Wisconsin Foundation |
45730 |
0.3% |
| ALLIANCEBERNSTEIN L.P. |
44570 |
0.2% |
| Sofinnova Investments, Inc. |
44417 |
0.2% |
| Propel Bio Management, LLC |
43032 |
0.2% |
| VOYA INVESTMENT MANAGEMENT LLC |
43020 |
0.2% |
| Point72 Asset Management, L.P. |
40958 |
0.2% |
| GILDER GAGNON HOWE & CO LLC |
38377 |
0.2% |
| Rafferty Asset Management, LLC |
36418 |
0.2% |
| JANE STREET GROUP, LLC |
36204 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
35678 |
0.2% |
| Skandinaviska Enskilda Banken AB (publ) |
35112 |
0.2% |
| Handelsbanken Fonder AB |
31600 |
0.2% |
| PFM Health Sciences, LP |
29973 |
0.2% |
| WELLS FARGO & COMPANY/MN |
29635 |
0.2% |
| MACQUARIE GROUP LTD |
28500 |
0.2% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
27538 |
0.2% |
| Rhenman & Partners Asset Management AB |
26500 |
0.1% |
| T. Rowe Price Investment Management, Inc. |
25644 |
0.1% |
| RHUMBLINE ADVISERS |
25351 |
0.1% |
| Swiss National Bank |
24800 |
0.1% |
| Schonfeld Strategic Advisors LLC |
24460 |
0.1% |
| Rokos Capital Management LLP |
23649 |
0.1% |
| Simplify Asset Management Inc. |
23302 |
0.1% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
22262 |
0.1% |
| WINTRUST INVESTMENTS LLC |
21370 |
0.1% |
| Hennion & Walsh Asset Management, Inc. |
20337 |
0.1% |
| RAYMOND JAMES & ASSOCIATES |
20321 |
0.1% |
| Rockefeller Capital Management L.P. |
19088 |
0.1% |
| CITIGROUP INC |
16062 |
0.1% |
| CAPITAL FUND MANAGEMENT S.A. |
15762 |
0.1% |
| BARCLAYS PLC |
15196 |
0.1% |
| Legal & General Group Plc |
14633 |
0.1% |
| ENVESTNET ASSET MANAGEMENT INC |
14454 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
14162 |
0.1% |
| JOURNEY STRATEGIC WEALTH LLC |
13325 |
0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
12708 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12659 |
0.1% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
11348 |
0.1% |
| CITADEL ADVISORS LLC |
11190 |
0.1% |
| MetLife Investment Management, LLC |
10123 |
0.1% |
| EULAV Asset Management |
10000 |
0.1% |
| SEI INVESTMENTS CO |
9799 |
0.1% |
| Russell Investments Group, Ltd. |
9302 |
0.1% |
| CASTLEARK MANAGEMENT LLC |
9130 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
9087 |
0.1% |
| State of New Jersey Common Pension Fund D |
8107 |
44.9‰ |
| DekaBank Deutsche Girozentrale |
8000 |
44.3‰ |
| BNP PARIBAS FINANCIAL MARKETS |
6921 |
38.3‰ |
