| FARALLON CAPITAL MANAGEMENT LLC |
5654502 |
10.2% |
| VANGUARD GROUP INC |
5496737 |
9.9% |
| BlackRock, Inc. |
5016260 |
9.1% |
| BlackRock Finance, Inc. |
4859002 |
8.8% |
| Bellevue Group AG |
3879548 |
7.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
2777259 |
5.0% |
| DIMENSIONAL FUND ADVISORS LP |
2196085 |
4.0% |
| STATE STREET CORP |
2114949 |
3.8% |
| ARMISTICE CAPITAL, LLC |
2079151 |
3.8% |
| Erste Asset Management GmbH |
2009900 |
3.6% |
| JPMORGAN CHASE & CO |
1776145 |
3.2% |
| MACQUARIE GROUP LTD |
1729729 |
3.1% |
| GEODE CAPITAL MANAGEMENT, LLC |
1351430 |
2.4% |
| BVF INC/IL |
1190107 |
2.1% |
| MARSHALL WACE, LLP |
1133735 |
2.0% |
| Rock Springs Capital Management LP |
1044261 |
1.9% |
| ArrowMark Colorado Holdings LLC |
1019357 |
1.8% |
| BNP Paribas Asset Management Holding S.A. |
911175 |
1.6% |
| Frazier Life Sciences Management, L.P. |
871974 |
1.6% |
| Fisher Asset Management, LLC |
709912 |
1.3% |
| D. E. Shaw & Co., Inc. |
678234 |
1.2% |
| DEUTSCHE BANK AG\ |
662236 |
1.2% |
| MORGAN STANLEY |
596675 |
1.1% |
| GW&K Investment Management, LLC |
595066 |
1.1% |
| NORTHERN TRUST CORP |
586266 |
1.1% |
| GOLDMAN SACHS GROUP INC |
549003 |
1.0% |
| Caligan Partners LP |
514711 |
0.9% |
| Schonfeld Strategic Advisors LLC |
464121 |
0.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
457527 |
0.8% |
| LOOMIS SAYLES & CO L P |
448863 |
0.8% |
| Pictet Asset Management Holding SA |
422044 |
0.8% |
| Eagle Health Investments LP |
330830 |
0.6% |
| BANK OF AMERICA CORP /DE/ |
326780 |
0.6% |
| Candriam S.C.A. |
322882 |
0.6% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
320531 |
0.6% |
| Artisan Partners Limited Partnership |
320467 |
0.6% |
| Nuveen Asset Management, LLC |
317941 |
0.6% |
| CenterBook Partners LP |
249311 |
0.4% |
| Laurion Capital Management LP |
248395 |
0.4% |
| NORGES BANK |
242734 |
0.4% |
| AXA S.A. |
238682 |
0.4% |
| NORDEA INVESTMENT MANAGEMENT AB |
224855 |
0.4% |
| BOOTHBAY FUND MANAGEMENT, LLC |
223979 |
0.4% |
| Bank of New York Mellon Corp |
223151 |
0.4% |
| TD ASSET MANAGEMENT INC |
210472 |
0.4% |
| JANE STREET GROUP, LLC |
176815 |
0.3% |
| PANAGORA ASSET MANAGEMENT INC |
174870 |
0.3% |
| Trexquant Investment LP |
155076 |
0.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
137844 |
0.2% |
| Granahan Investment Management, LLC |
136838 |
0.2% |
| Assenagon Asset Management S.A. |
134980 |
0.2% |
| FIRST TRUST ADVISORS LP |
130411 |
0.2% |
| CITADEL ADVISORS LLC |
123840 |
0.2% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
122835 |
0.2% |
| SECTOR GAMMA AS |
121844 |
0.2% |
| Invesco Ltd. |
118020 |
0.2% |
| Hudson Bay Capital Management LP |
115000 |
0.2% |
| Woodline Partners LP |
113378 |
0.2% |
| Allianz Asset Management GmbH |
111558 |
0.2% |
| BARCLAYS PLC |
109881 |
0.2% |
| PRUDENTIAL FINANCIAL INC |
107852 |
0.2% |
| RHUMBLINE ADVISERS |
101180 |
0.2% |
| Swiss National Bank |
99460 |
0.2% |
| AMERICAN CENTURY COMPANIES INC |
94486 |
0.2% |
| KENNEDY CAPITAL MANAGEMENT LLC |
83661 |
0.2% |
| ACUTA CAPITAL PARTNERS, LLC |
78700 |
0.1% |
| Rafferty Asset Management, LLC |
76853 |
0.1% |
| PDT Partners, LLC |
75280 |
0.1% |
| EAM Investors, LLC |
74142 |
0.1% |
| AMERIPRISE FINANCIAL INC |
71889 |
0.1% |
| UBS Group AG |
69359 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
65122 |
0.1% |
| Legal & General Group Plc |
60725 |
0.1% |
| MOORE CAPITAL MANAGEMENT, LP |
60000 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
49830 |
0.1% |
| State of New Jersey Common Pension Fund D |
48943 |
0.1% |
| ALPS ADVISORS INC |
44292 |
0.1% |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
43330 |
0.1% |
| Edgestream Partners, L.P. |
42076 |
0.1% |
| BALYASNY ASSET MANAGEMENT L.P. |
41793 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
40407 |
0.1% |
| ALGERT GLOBAL LLC |
40256 |
0.1% |
| DekaBank Deutsche Girozentrale |
40000 |
0.1% |
| WELLS FARGO & COMPANY/MN |
39979 |
0.1% |
| SEVEN EIGHT CAPITAL, LP |
39262 |
0.1% |
| NEW YORK STATE COMMON RETIREMENT FUND |
38195 |
0.1% |
| CAXTON ASSOCIATES LP |
37453 |
0.1% |
| Connor, Clark & Lunn Investment Management Ltd. |
37281 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
36498 |
0.1% |
| WELLINGTON MANAGEMENT GROUP LLP |
36419 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
35634 |
0.1% |
| MARTINGALE ASSET MANAGEMENT L P |
35293 |
0.1% |
| OAK RIDGE INVESTMENTS LLC |
35236 |
0.1% |
| AQR CAPITAL MANAGEMENT LLC |
33164 |
0.1% |
| HARBOR CAPITAL ADVISORS, INC. |
32770 |
0.1% |
| MetLife Investment Management, LLC |
32663 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
31087 |
0.1% |
| EDGEWOOD MANAGEMENT LLC |
30000 |
0.1% |
| Skandinaviska Enskilda Banken AB (publ) |
29360 |
0.1% |
| JANUS HENDERSON GROUP PLC |
25897 |
46.7‰ |
