| FMR LLC |
4283766 |
15.9% |
| BlackRock, Inc. |
4033872 |
15.0% |
| BlackRock Finance, Inc. |
3947845 |
14.6% |
| VANGUARD GROUP INC |
2869136 |
10.6% |
| Avoro Capital Advisors LLC |
2433000 |
9.0% |
| STATE STREET CORP |
1332875 |
4.9% |
| Redmile Group, LLC |
1021078 |
3.8% |
| Frazier Life Sciences Management, L.P. |
988460 |
3.7% |
| Capital World Investors |
878158 |
3.3% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
600145 |
2.2% |
| DIMENSIONAL FUND ADVISORS LP |
580452 |
2.2% |
| GEODE CAPITAL MANAGEMENT, LLC |
580220 |
2.2% |
| Hood River Capital Management LLC |
521093 |
1.9% |
| JENNISON ASSOCIATES LLC |
520390 |
1.9% |
| GOLDMAN SACHS GROUP INC |
422331 |
1.6% |
| LORD, ABBETT & CO. LLC |
392238 |
1.5% |
| Nuveen Asset Management, LLC |
336170 |
1.2% |
| MORGAN STANLEY |
318327 |
1.2% |
| Woodline Partners LP |
291918 |
1.1% |
| Invesco Ltd. |
275077 |
1.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
220439 |
0.8% |
| NORTHERN TRUST CORP |
218461 |
0.8% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
210202 |
0.8% |
| Bank of New York Mellon Corp |
193767 |
0.7% |
| Skandinaviska Enskilda Banken AB (publ) |
191515 |
0.7% |
| FRANKLIN RESOURCES INC |
181582 |
0.7% |
| Allspring Global Investments Holdings, LLC |
176446 |
0.7% |
| BAKER BROS. ADVISORS LP |
169934 |
0.6% |
| JPMORGAN CHASE & CO |
163824 |
0.6% |
| VICTORY CAPITAL MANAGEMENT INC |
143865 |
0.5% |
| Pictet Asset Management Holding SA |
137433 |
0.5% |
| EVENTIDE ASSET MANAGEMENT, LLC |
136485 |
0.5% |
| C WorldWide Group Holding A/S |
135809 |
0.5% |
| Soleus Capital Management, L.P. |
126000 |
0.5% |
| PRINCIPAL FINANCIAL GROUP INC |
123469 |
0.5% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
118746 |
0.4% |
| First Turn Management, LLC |
109222 |
0.4% |
| Handelsbanken Fonder AB |
106500 |
0.4% |
| Rock Springs Capital Management LP |
105569 |
0.4% |
| AMERIPRISE FINANCIAL INC |
101996 |
0.4% |
| BANK OF AMERICA CORP /DE/ |
93629 |
0.3% |
| S Squared Technology, LLC |
85215 |
0.3% |
| Integral Health Asset Management, LLC |
85000 |
0.3% |
| TimesSquare Capital Management, LLC |
83039 |
0.3% |
| JANE STREET GROUP, LLC |
77832 |
0.3% |
| EAGLE ASSET MANAGEMENT INC |
76259 |
0.3% |
| VOYA INVESTMENT MANAGEMENT LLC |
72877 |
0.3% |
| RHUMBLINE ADVISERS |
71685 |
0.3% |
| Man Group plc |
69250 |
0.3% |
| Legal & General Group Plc |
66103 |
0.2% |
| Decheng Capital LLC |
65772 |
0.2% |
| BALYASNY ASSET MANAGEMENT L.P. |
59810 |
0.2% |
| TD ASSET MANAGEMENT INC |
58080 |
0.2% |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
54656 |
0.2% |
| SCOUT INVESTMENTS, INC. |
46553 |
0.2% |
| PRUDENTIAL FINANCIAL INC |
46538 |
0.2% |
| abrdn plc |
43372 |
0.2% |
| OBERWEIS ASSET MANAGEMENT INC/ |
42600 |
0.2% |
| Rafferty Asset Management, LLC |
41800 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
41015 |
0.2% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
40380 |
0.1% |
| SEI INVESTMENTS CO |
40115 |
0.1% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
37324 |
0.1% |
| GW&K Investment Management, LLC |
37126 |
0.1% |
| Swiss National Bank |
36200 |
0.1% |
| SEGALL BRYANT & HAMILL, LLC |
34737 |
0.1% |
| Janney Montgomery Scott LLC |
31632 |
0.1% |
| ORBIMED ADVISORS LLC |
29966 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
29720 |
0.1% |
| EAM Global Investors LLC |
28843 |
0.1% |
| UBS Group AG |
28556 |
0.1% |
| NEW YORK STATE COMMON RETIREMENT FUND |
28381 |
0.1% |
| CASTLEARK MANAGEMENT LLC |
28280 |
0.1% |
| CANADA LIFE ASSURANCE Co |
26754 |
0.1% |
| EAM Investors, LLC |
26284 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
25310 |
0.1% |
| ALPS ADVISORS INC |
22270 |
0.1% |
| Hennion & Walsh Asset Management, Inc. |
21650 |
0.1% |
| CITIGROUP INC |
21210 |
0.1% |
| Hillsdale Investment Management Inc. |
21000 |
0.1% |
| THRIVENT FINANCIAL FOR LUTHERANS |
20625 |
0.1% |
| BARCLAYS PLC |
19088 |
0.1% |
| Rhenman & Partners Asset Management AB |
19000 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18425 |
0.1% |
| Erste Asset Management GmbH |
18200 |
0.1% |
| Verition Fund Management LLC |
17989 |
0.1% |
| Nicholas Investment Partners, LP |
17327 |
0.1% |
| Fiera Capital Corp |
16208 |
0.1% |
| CWM, LLC |
15618 |
0.1% |
| DekaBank Deutsche Girozentrale |
15503 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
15205 |
0.1% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
14900 |
0.1% |
| ExodusPoint Capital Management, LP |
14892 |
0.1% |
| State of Alaska, Department of Revenue |
14587 |
0.1% |
| WELLS FARGO & COMPANY/MN |
14490 |
0.1% |
| MetLife Investment Management, LLC |
14317 |
0.1% |
| Redwood Investments, LLC |
13929 |
0.1% |
| EFG Asset Management (North America) Corp. |
12555 |
46.6‰ |
| Louisiana State Employees Retirement System |
12500 |
46.4‰ |
| DEUTSCHE BANK AG\ |
12270 |
45.5‰ |
