| TCG Crossover Management, LLC |
2008340 |
2.0% |
| BML Capital Management, LLC |
1966000 |
2.0% |
| FRANKLIN RESOURCES INC |
1760052 |
1.8% |
| BlackRock, Inc. |
1485282 |
1.5% |
| BlackRock Finance, Inc. |
1409441 |
1.4% |
| Frazier Life Sciences Management, L.P. |
1069244 |
1.1% |
| VANGUARD GROUP INC |
1009459 |
1.0% |
| Vivo Capital, LLC |
833333 |
0.8% |
| FMR LLC |
637509 |
0.6% |
| Assenagon Asset Management S.A. |
617910 |
0.6% |
| 5AM Venture Management, LLC |
541666 |
0.5% |
| Versant Venture Management, LLC |
506821 |
0.5% |
| GEODE CAPITAL MANAGEMENT, LLC |
455787 |
0.5% |
| Avoro Capital Advisors LLC |
416666 |
0.4% |
| Logos Global Management LP |
416666 |
0.4% |
| GOLDMAN SACHS GROUP INC |
396931 |
0.4% |
| STATE STREET CORP |
278504 |
0.3% |
| DIMENSIONAL FUND ADVISORS LP |
223427 |
0.2% |
| MARSHALL WACE, LLP |
204619 |
0.2% |
| BANK OF AMERICA CORP /DE/ |
176099 |
0.2% |
| Soleus Capital Management, L.P. |
147246 |
0.1% |
| RENAISSANCE TECHNOLOGIES LLC |
136257 |
0.1% |
| MORGAN STANLEY |
129259 |
0.1% |
| CITADEL ADVISORS LLC |
125790 |
0.1% |
| PICTON MAHONEY ASSET MANAGEMENT |
123743 |
0.1% |
| TWO SIGMA INVESTMENTS, LP |
77345 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
69411 |
0.1% |
| Nuveen Asset Management, LLC |
68537 |
0.1% |
| Bank of New York Mellon Corp |
64585 |
0.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
59734 |
0.1% |
| NORTHERN TRUST CORP |
47163 |
46.9‰ |
| RHUMBLINE ADVISERS |
30821 |
30.7‰ |
| JANE STREET GROUP, LLC |
29202 |
29.1‰ |
| GROUP ONE TRADING LLC |
28266 |
28.1‰ |
| Quinn Opportunity Partners LLC |
26829 |
26.7‰ |
| TWO SIGMA ADVISERS, LP |
22901 |
22.8‰ |
| Qube Research & Technologies Ltd |
16265 |
16.2‰ |
| BANK OF MONTREAL /CAN/ |
16242 |
16.2‰ |
| BARCLAYS PLC |
15867 |
15.8‰ |
| CANTOR FITZGERALD, L. P. |
15446 |
15.4‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
14400 |
14.3‰ |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
12072 |
12.0‰ |
| Graham Capital Management, L.P. |
11782 |
11.7‰ |
| Bayesian Capital Management, LP |
10756 |
10.7‰ |
| WELLS FARGO & COMPANY/MN |
9140 |
9.1‰ |
| JPMORGAN CHASE & CO |
8904 |
8.9‰ |
| OSAIC HOLDINGS, INC. |
8574 |
8.5‰ |
| UBS Group AG |
6358 |
6.3‰ |
| MetLife Investment Management, LLC |
5493 |
5.5‰ |
| CITIGROUP INC |
4669 |
4.6‰ |
| BNP PARIBAS FINANCIAL MARKETS |
2537 |
2.5‰ |
| Ameritas Investment Partners, Inc. |
2038 |
2.0‰ |
| Legal & General Group Plc |
1797 |
1.8‰ |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
1507 |
1.5‰ |
| Tower Research Capital LLC (TRC) |
1461 |
1.5‰ |
| AMALGAMATED BANK |
720 |
0.7‰ |
| SIMPLEX TRADING, LLC |
322 |
0.3‰ |
| Parallel Advisors, LLC |
50 |
< 0.1‰ |
| LAZARD ASSET MANAGEMENT LLC |
46 |
< 0.1‰ |
| GHP Investment Advisors, Inc. |
20 |
< 0.1‰ |
| DEUTSCHE BANK AG\ |
2 |
< 0.1‰ |
| Allworth Financial LP |
2 |
< 0.1‰ |
| Frazier Financial Advisors, LLC |
1 |
< 0.1‰ |
