| BlackRock, Inc. |
9884617 |
21.3% |
| FARALLON CAPITAL MANAGEMENT LLC |
5840773 |
12.6% |
| BlackRock Finance, Inc. |
5758112 |
12.4% |
| RTW INVESTMENTS, LP |
5286404 |
11.4% |
| BVF INC/IL |
3319290 |
7.2% |
| VANGUARD GROUP INC |
3243473 |
7.0% |
| JOHNSON & JOHNSON |
2449183 |
5.3% |
| STATE STREET CORP |
2082324 |
4.5% |
| Jefferies Financial Group Inc. |
2040561 |
4.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
2001342 |
4.3% |
| GEODE CAPITAL MANAGEMENT, LLC |
1371169 |
3.0% |
| PERCEPTIVE ADVISORS LLC |
1268735 |
2.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1209542 |
2.6% |
| COWEN AND COMPANY, LLC |
1182268 |
2.6% |
| ADAR1 Capital Management, LLC |
1020333 |
2.2% |
| MILLENNIUM MANAGEMENT LLC |
958283 |
2.1% |
| Fairmount Funds Management LLC |
931890 |
2.0% |
| Point72 Asset Management, L.P. |
909734 |
2.0% |
| DEUTSCHE BANK AG\ |
908348 |
2.0% |
| Woodline Partners LP |
822173 |
1.8% |
| Kynam Capital Management, LP |
800000 |
1.7% |
| DIMENSIONAL FUND ADVISORS LP |
616172 |
1.3% |
| 683 Capital Management, LLC |
604449 |
1.3% |
| GOLDMAN SACHS GROUP INC |
590761 |
1.3% |
| MARSHALL WACE, LLP |
572177 |
1.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
556835 |
1.2% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
525653 |
1.1% |
| NORTHERN TRUST CORP |
508459 |
1.1% |
| Eversept Partners, LP |
505836 |
1.1% |
| Qube Research & Technologies Ltd |
453152 |
1.0% |
| MANGROVE PARTNERS IM, LLC |
439314 |
0.9% |
| FMR LLC |
434459 |
0.9% |
| Gratus Capital, LLC |
418346 |
0.9% |
| JPMORGAN CHASE & CO |
376588 |
0.8% |
| Nuveen Asset Management, LLC |
373992 |
0.8% |
| EAGLE ASSET MANAGEMENT INC |
357633 |
0.8% |
| Checkpoint Capital L.P. |
355000 |
0.8% |
| MORGAN STANLEY |
345293 |
0.7% |
| BANK OF AMERICA CORP /DE/ |
300481 |
0.6% |
| RENAISSANCE TECHNOLOGIES LLC |
297467 |
0.6% |
| KENNEDY CAPITAL MANAGEMENT LLC |
290082 |
0.6% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
287911 |
0.6% |
| Candriam S.C.A. |
273818 |
0.6% |
| Bank of New York Mellon Corp |
204299 |
0.4% |
| Rubric Capital Management LP |
198059 |
0.4% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
191168 |
0.4% |
| JANE STREET GROUP, LLC |
169311 |
0.4% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
157788 |
0.3% |
| ALGERT GLOBAL LLC |
152079 |
0.3% |
| TD ASSET MANAGEMENT INC |
148302 |
0.3% |
| STEMPOINT CAPITAL LP |
141714 |
0.3% |
| MOODY ALDRICH PARTNERS LLC |
134215 |
0.3% |
| FIRST TRUST ADVISORS LP |
131810 |
0.3% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
129011 |
0.3% |
| Artia Global Partners LP |
124440 |
0.3% |
| SEGALL BRYANT & HAMILL, LLC |
118562 |
0.3% |
| TWO SIGMA ADVISERS, LP |
116600 |
0.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
114406 |
0.2% |
| Opaleye Management Inc. |
105000 |
0.2% |
| ALLIANCEBERNSTEIN L.P. |
95169 |
0.2% |
| GREAT LAKES ADVISORS, LLC |
93479 |
0.2% |
| Invesco Ltd. |
88434 |
0.2% |
| Swiss National Bank |
85900 |
0.2% |
| RHUMBLINE ADVISERS |
84975 |
0.2% |
| Cubist Systematic Strategies, LLC |
84202 |
0.2% |
| Connor, Clark & Lunn Investment Management Ltd. |
82791 |
0.2% |
| TWO SIGMA INVESTMENTS, LP |
82637 |
0.2% |
| Trexquant Investment LP |
80614 |
0.2% |
| Rafferty Asset Management, LLC |
75270 |
0.2% |
| Cannon Global Investment Management, LLC |
69900 |
0.2% |
| UBS Group AG |
66981 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
65066 |
0.1% |
| Twin Lakes Capital Management, LLC |
62439 |
0.1% |
| DARK FOREST CAPITAL MANAGEMENT LP |
60962 |
0.1% |
| Legal & General Group Plc |
59537 |
0.1% |
| OLD MISSION CAPITAL LLC |
58916 |
0.1% |
| CANADA LIFE ASSURANCE Co |
56536 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
55951 |
0.1% |
| Swedbank AB |
50000 |
0.1% |
| Schonfeld Strategic Advisors LLC |
49064 |
0.1% |
| Birchview Capital, LP |
48000 |
0.1% |
| ALPS ADVISORS INC |
45772 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
43795 |
0.1% |
| SEI INVESTMENTS CO |
41763 |
0.1% |
| BARCLAYS PLC |
39240 |
0.1% |
| Hennion & Walsh Asset Management, Inc. |
37880 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
37055 |
0.1% |
| SEVEN EIGHT CAPITAL, LP |
36793 |
0.1% |
| FRANKLIN RESOURCES INC |
35917 |
0.1% |
| Jackson Creek Investment Advisors LLC |
34651 |
0.1% |
| MetLife Investment Management, LLC |
33805 |
0.1% |
| Capula Management Ltd |
32963 |
0.1% |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
30827 |
0.1% |
| WELLS FARGO & COMPANY/MN |
30190 |
0.1% |
| AMERICAN CENTURY COMPANIES INC |
27311 |
0.1% |
| State of Tennessee, Department of Treasury |
27076 |
0.1% |
| AQR CAPITAL MANAGEMENT LLC |
25055 |
0.1% |
| GSA CAPITAL PARTNERS LLP |
25029 |
0.1% |
| AlphaCentric Advisors LLC |
25000 |
0.1% |
| STRS OHIO |
24900 |
0.1% |
