| venBio Partners LLC |
9699925 |
23.7% |
| FMR LLC |
7814996 |
19.1% |
| Vivo Capital, LLC |
4220048 |
10.3% |
| Redmile Group, LLC |
4036451 |
9.9% |
| BlackRock Finance, Inc. |
2687619 |
6.6% |
| BlackRock, Inc. |
2384247 |
5.8% |
| MPM BioImpact LLC |
2180864 |
5.3% |
| ORBIMED ADVISORS LLC |
1894462 |
4.6% |
| VANGUARD GROUP INC |
1727248 |
4.2% |
| Paradigm Biocapital Advisors LP |
1575605 |
3.9% |
| MILLENNIUM MANAGEMENT LLC |
1325196 |
3.2% |
| STATE STREET CORP |
705547 |
1.7% |
| GEODE CAPITAL MANAGEMENT, LLC |
700406 |
1.7% |
| MORGAN STANLEY |
673358 |
1.6% |
| MARSHALL WACE, LLP |
635679 |
1.6% |
| RENAISSANCE TECHNOLOGIES LLC |
438200 |
1.1% |
| Privium Fund Management B.V. |
396966 |
1.0% |
| KENNEDY CAPITAL MANAGEMENT LLC |
307529 |
0.8% |
| Point72 Asset Management, L.P. |
304100 |
0.7% |
| TWO SIGMA INVESTMENTS, LP |
292226 |
0.7% |
| NORTHERN TRUST CORP |
244551 |
0.6% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
236020 |
0.6% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
232022 |
0.6% |
| GOLDMAN SACHS GROUP INC |
215252 |
0.5% |
| Cubist Systematic Strategies, LLC |
199441 |
0.5% |
| WELLINGTON MANAGEMENT GROUP LLP |
145717 |
0.4% |
| Walleye Capital LLC |
109762 |
0.3% |
| Nuveen Asset Management, LLC |
105894 |
0.3% |
| Bank of New York Mellon Corp |
104966 |
0.3% |
| JANE STREET GROUP, LLC |
78100 |
0.2% |
| STATE OF WISCONSIN INVESTMENT BOARD |
75120 |
0.2% |
| ALLIANCEBERNSTEIN L.P. |
71730 |
0.2% |
| CITADEL ADVISORS LLC |
68511 |
0.2% |
| TWO SIGMA ADVISERS, LP |
67600 |
0.2% |
| abrdn plc |
66211 |
0.2% |
| Inspire Investing, LLC |
58707 |
0.1% |
| RHUMBLINE ADVISERS |
55220 |
0.1% |
| Swiss National Bank |
49400 |
0.1% |
| BALYASNY ASSET MANAGEMENT L.P. |
44149 |
0.1% |
| Nan Fung Group Holdings Ltd |
41950 |
0.1% |
| ALGERT GLOBAL LLC |
41215 |
0.1% |
| BANK OF AMERICA CORP /DE/ |
41010 |
0.1% |
| DekaBank Deutsche Girozentrale |
41000 |
0.1% |
| JPMORGAN CHASE & CO |
40425 |
0.1% |
| DIMENSIONAL FUND ADVISORS LP |
34543 |
0.1% |
| Verition Fund Management LLC |
32571 |
0.1% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
31419 |
0.1% |
| Legal & General Group Plc |
28926 |
0.1% |
| Connor, Clark & Lunn Investment Management Ltd. |
27014 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25254 |
0.1% |
| LMR Partners LLP |
25000 |
0.1% |
| Graham Capital Management, L.P. |
23942 |
0.1% |
| AMERICAN CENTURY COMPANIES INC |
23685 |
0.1% |
| SHERBROOKE PARK ADVISERS LLC |
22172 |
0.1% |
| SG Americas Securities, LLC |
20506 |
0.1% |
| D. E. Shaw & Co., Inc. |
18940 |
46.3‰ |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
18913 |
46.2‰ |
| AQR CAPITAL MANAGEMENT LLC |
18079 |
44.2‰ |
| BARCLAYS PLC |
17317 |
42.3‰ |
| OCCUDO QUANTITATIVE STRATEGIES LP |
16402 |
40.1‰ |
| MetLife Investment Management, LLC |
16140 |
39.5‰ |
| UBS Group AG |
15453 |
37.8‰ |
| GROUP ONE TRADING LLC |
15112 |
36.9‰ |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
13662 |
33.4‰ |
| Engineers Gate Manager LP |
12600 |
30.8‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
12522 |
30.6‰ |
| BNP PARIBAS FINANCIAL MARKETS |
11417 |
27.9‰ |
| VOYA INVESTMENT MANAGEMENT LLC |
11215 |
27.4‰ |
| HSBC HOLDINGS PLC |
10780 |
26.4‰ |
| Virtus ETF Advisers LLC |
10726 |
26.2‰ |
| PRICE T ROWE ASSOCIATES INC /MD/ |
10622 |
26.0‰ |
| WELLS FARGO & COMPANY/MN |
10575 |
25.9‰ |
| DEUTSCHE BANK AG\ |
10434 |
25.5‰ |
| CORNERCAP INVESTMENT COUNSEL INC |
10292 |
25.2‰ |
| Invesco Ltd. |
10290 |
25.2‰ |
| TUDOR INVESTMENT CORP ET AL |
10098 |
24.7‰ |
| CITIGROUP INC |
8292 |
20.3‰ |
| Tower Research Capital LLC (TRC) |
7579 |
18.5‰ |
| Caption Management, LLC |
6600 |
16.1‰ |
| Zurcher Kantonalbank (Zurich Cantonalbank) |
6517 |
15.9‰ |
| China Universal Asset Management Co., Ltd. |
6122 |
15.0‰ |
| STRS OHIO |
4100 |
10.0‰ |
| Ameritas Investment Partners, Inc. |
2790 |
6.8‰ |
| Russell Investments Group, Ltd. |
2331 |
5.7‰ |
| FEDERATED HERMES, INC. |
2329 |
5.7‰ |
| Mirae Asset Global Investments Co., Ltd. |
1555 |
3.8‰ |
| MassMutual Private Wealth & Trust, FSB |
1270 |
3.1‰ |
| Bradley & Co. Private Wealth Management, LLC |
1000 |
2.4‰ |
| AMALGAMATED BANK |
897 |
2.2‰ |
| Smartleaf Asset Management LLC |
631 |
1.5‰ |
| NISA INVESTMENT ADVISORS, LLC |
606 |
1.5‰ |
| Qube Research & Technologies Ltd |
571 |
1.4‰ |
| COMERICA BANK |
411 |
1.0‰ |
| ROTHSCHILD INVESTMENT LLC |
390 |
1.0‰ |
| Lindbrook Capital, LLC |
282 |
0.7‰ |
| Parallel Advisors, LLC |
204 |
0.5‰ |
| Daiwa Securities Group Inc. |
138 |
0.3‰ |
| PNC FINANCIAL SERVICES GROUP, INC. |
131 |
0.3‰ |
| CWM, LLC |
85 |
0.2‰ |
| OSAIC HOLDINGS, INC. |
51 |
0.1‰ |
