| EcoR1 Capital, LLC |
19364688 |
31.5% |
| Nextech Invest Ltd. |
9526146 |
15.5% |
| BlackRock, Inc. |
9205182 |
15.0% |
| Bain Capital Life Sciences Investors, LLC |
8663673 |
14.1% |
| BlackRock Finance, Inc. |
8383910 |
13.6% |
| VANGUARD GROUP INC |
6702521 |
10.9% |
| Rock Springs Capital Management LP |
3046782 |
5.0% |
| Schonfeld Strategic Advisors LLC |
2976918 |
4.8% |
| CITADEL ADVISORS LLC |
2743599 |
4.5% |
| STATE STREET CORP |
2682055 |
4.4% |
| Cormorant Asset Management, LP |
2600000 |
4.2% |
| SILVERARC CAPITAL MANAGEMENT, LLC |
2500585 |
4.1% |
| GEODE CAPITAL MANAGEMENT, LLC |
2493423 |
4.1% |
| MORGAN STANLEY |
2272594 |
3.7% |
| JPMORGAN CHASE & CO |
1976899 |
3.2% |
| ACUTA CAPITAL PARTNERS, LLC |
1663000 |
2.7% |
| DEUTSCHE BANK AG\ |
1576000 |
2.6% |
| Woodline Partners LP |
1467311 |
2.4% |
| D. E. Shaw & Co., Inc. |
1465580 |
2.4% |
| RENAISSANCE TECHNOLOGIES LLC |
1448219 |
2.4% |
| 5AM Venture Management, LLC |
1305000 |
2.1% |
| GOLDMAN SACHS GROUP INC |
1244937 |
2.0% |
| BAKER BROS. ADVISORS LP |
1086115 |
1.8% |
| Qube Research & Technologies Ltd |
992565 |
1.6% |
| Octagon Capital Advisors LP |
992000 |
1.6% |
| NORTHERN TRUST CORP |
900621 |
1.5% |
| Affinity Asset Advisors, LLC |
767000 |
1.2% |
| TWO SIGMA INVESTMENTS, LP |
748690 |
1.2% |
| TWO SIGMA ADVISERS, LP |
719300 |
1.2% |
| MILLENNIUM MANAGEMENT LLC |
691785 |
1.1% |
| WELLINGTON MANAGEMENT GROUP LLP |
532866 |
0.9% |
| ClariVest Asset Management LLC |
500498 |
0.8% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
485593 |
0.8% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
475500 |
0.8% |
| Bank of New York Mellon Corp |
452829 |
0.7% |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
410029 |
0.7% |
| BARCLAYS PLC |
372717 |
0.6% |
| Atom Investors LP |
365435 |
0.6% |
| BNP PARIBAS FINANCIAL MARKETS |
361147 |
0.6% |
| JANE STREET GROUP, LLC |
317332 |
0.5% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
312630 |
0.5% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
308691 |
0.5% |
| HRT FINANCIAL LP |
259689 |
0.4% |
| FMR LLC |
245408 |
0.4% |
| PANAGORA ASSET MANAGEMENT INC |
236225 |
0.4% |
| ALLIANCEBERNSTEIN L.P. |
186060 |
0.3% |
| FEDERATED HERMES, INC. |
185507 |
0.3% |
| HealthInvest Partners AB |
184900 |
0.3% |
| RHUMBLINE ADVISERS |
176063 |
0.3% |
| MARSHALL WACE, LLP |
176029 |
0.3% |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
175420 |
0.3% |
| Exome Asset Management LLC |
172924 |
0.3% |
| BANK OF AMERICA CORP /DE/ |
159773 |
0.3% |
| MACQUARIE GROUP LTD |
150000 |
0.2% |
| SG Americas Securities, LLC |
138722 |
0.2% |
| Nuveen Asset Management, LLC |
123339 |
0.2% |
| XTX Topco Ltd |
121432 |
0.2% |
| ExodusPoint Capital Management, LP |
107174 |
0.2% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
99078 |
0.2% |
| STATE OF WISCONSIN INVESTMENT BOARD |
83600 |
0.1% |
| ACADIAN ASSET MANAGEMENT LLC |
71506 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
65936 |
0.1% |
| MetLife Investment Management, LLC |
65583 |
0.1% |
| QVT Financial LP |
62657 |
0.1% |
| GSA CAPITAL PARTNERS LLP |
57960 |
0.1% |
| GROUP ONE TRADING LLC |
52283 |
0.1% |
| Graham Capital Management, L.P. |
50970 |
0.1% |
| AIGEN INVESTMENT MANAGEMENT, LP |
50083 |
0.1% |
| WELLS FARGO & COMPANY/MN |
47270 |
0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
46487 |
0.1% |
| AMERIPRISE FINANCIAL INC |
45547 |
0.1% |
| Invesco Ltd. |
45056 |
0.1% |
| ALGERT GLOBAL LLC |
44655 |
0.1% |
| EXCHANGE TRADED CONCEPTS, LLC |
43420 |
0.1% |
| Tower Research Capital LLC (TRC) |
40760 |
0.1% |
| SIMPLEX TRADING, LLC |
38661 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
38588 |
0.1% |
| NEW YORK STATE COMMON RETIREMENT FUND |
37235 |
0.1% |
| UBS Group AG |
34983 |
0.1% |
| Walleye Trading LLC |
31526 |
0.1% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
28800 |
46.8‰ |
| CITIGROUP INC |
25566 |
41.6‰ |
| Jasper Ridge Partners, L.P. |
23100 |
37.6‰ |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
20587 |
33.5‰ |
| PRINCIPAL FINANCIAL GROUP INC |
18278 |
29.7‰ |
| NISA INVESTMENT ADVISORS, LLC |
17800 |
29.0‰ |
| PRUDENTIAL FINANCIAL INC |
17335 |
28.2‰ |
| GRIMES & COMPANY, INC. |
14998 |
24.4‰ |
| ProShare Advisors LLC |
14850 |
24.2‰ |
| DIMENSIONAL FUND ADVISORS LP |
13703 |
22.3‰ |
| HSBC HOLDINGS PLC |
12526 |
20.4‰ |
| VICTORY CAPITAL MANAGEMENT INC |
11873 |
19.3‰ |
| Legal & General Group Plc |
11097 |
18.0‰ |
| Verition Fund Management LLC |
11049 |
18.0‰ |
| Caption Management, LLC |
10200 |
16.6‰ |
| Ameritas Investment Partners, Inc. |
9896 |
16.1‰ |
| Russell Investments Group, Ltd. |
9516 |
15.5‰ |
| State of Wyoming |
9158 |
14.9‰ |
| STRS OHIO |
8700 |
14.1‰ |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8220 |
13.4‰ |
