| BAKER BROS. ADVISORS LP |
17310490 |
33.1% |
| BlackRock Finance, Inc. |
3846827 |
7.3% |
| BlackRock, Inc. |
3727531 |
7.1% |
| ACADIAN ASSET MANAGEMENT LLC |
1965449 |
3.8% |
| VANGUARD GROUP INC |
1655439 |
3.2% |
| SILVERARC CAPITAL MANAGEMENT, LLC |
1062062 |
2.0% |
| ICONIQ Capital, LLC |
1016864 |
1.9% |
| D. E. Shaw & Co., Inc. |
945152 |
1.8% |
| Newtyn Management, LLC |
930000 |
1.8% |
| TCG Crossover Management, LLC |
899999 |
1.7% |
| STATE STREET CORP |
801923 |
1.5% |
| GEODE CAPITAL MANAGEMENT, LLC |
755957 |
1.4% |
| RENAISSANCE TECHNOLOGIES LLC |
708800 |
1.4% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
699158 |
1.3% |
| Board of Trustees of The Leland Stanford Junior University |
691767 |
1.3% |
| Hudson Bay Capital Management LP |
538374 |
1.0% |
| Ikarian Capital, LLC |
476586 |
0.9% |
| Bruce & Co., Inc. |
423000 |
0.8% |
| MORGAN STANLEY |
405282 |
0.8% |
| DIMENSIONAL FUND ADVISORS LP |
368199 |
0.7% |
| GOLDMAN SACHS GROUP INC |
318229 |
0.6% |
| TWO SIGMA ADVISERS, LP |
300400 |
0.6% |
| BANK OF AMERICA CORP /DE/ |
295156 |
0.6% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
276550 |
0.5% |
| NORTHERN TRUST CORP |
244519 |
0.5% |
| Atom Investors LP |
199535 |
0.4% |
| MARSHALL WACE, LLP |
166425 |
0.3% |
| FMR LLC |
158984 |
0.3% |
| Nuveen Asset Management, LLC |
145449 |
0.3% |
| SEI INVESTMENTS CO |
143841 |
0.3% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
139200 |
0.3% |
| Acuitas Investments, LLC |
132502 |
0.3% |
| BOOTHBAY FUND MANAGEMENT, LLC |
129438 |
0.2% |
| TWO SIGMA INVESTMENTS, LP |
124411 |
0.2% |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
119129 |
0.2% |
| Bank of New York Mellon Corp |
117447 |
0.2% |
| Cubist Systematic Strategies, LLC |
99335 |
0.2% |
| PANAGORA ASSET MANAGEMENT INC |
88030 |
0.2% |
| PRUDENTIAL FINANCIAL INC |
79108 |
0.2% |
| Invesco Ltd. |
75467 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
71470 |
0.1% |
| JANE STREET GROUP, LLC |
64397 |
0.1% |
| DEUTSCHE BANK AG\ |
58094 |
0.1% |
| RHUMBLINE ADVISERS |
56511 |
0.1% |
| AMERICAN CENTURY COMPANIES INC |
54323 |
0.1% |
| BARCLAYS PLC |
48131 |
0.1% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
47869 |
0.1% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
47616 |
0.1% |
| HSBC HOLDINGS PLC |
42171 |
0.1% |
| AMERIPRISE FINANCIAL INC |
33628 |
0.1% |
| Nan Fung Group Holdings Ltd |
31922 |
0.1% |
| Graham Capital Management, L.P. |
29682 |
0.1% |
| STRS OHIO |
28800 |
0.1% |
| WELLS FARGO & COMPANY/MN |
25335 |
48.4‰ |
| HRT FINANCIAL LP |
24098 |
46.0‰ |
| Marquette Asset Management, LLC |
23930 |
45.7‰ |
| ADAR1 Capital Management, LLC |
23700 |
45.3‰ |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
18563 |
35.4‰ |
| PDT Partners, LLC |
16310 |
31.1‰ |
| MEEDER ASSET MANAGEMENT INC |
15137 |
28.9‰ |
| ZACKS INVESTMENT MANAGEMENT |
15015 |
28.7‰ |
| JGP Global Gestao de Recursos Ltda. |
14957 |
28.6‰ |
| Continuum Advisory, LLC |
14852 |
28.4‰ |
| Tower Research Capital LLC (TRC) |
14637 |
27.9‰ |
| LJI Wealth Management, LLC |
14100 |
26.9‰ |
| JPMORGAN CHASE & CO |
13913 |
26.6‰ |
| UBS Group AG |
13709 |
26.2‰ |
| MILLENNIUM MANAGEMENT LLC |
12757 |
24.4‰ |
| Vontobel Holding Ltd. |
11000 |
21.0‰ |
| OSAIC HOLDINGS, INC. |
10670 |
20.4‰ |
| Vanguard Personalized Indexing Management, LLC |
10351 |
19.8‰ |
| Walleye Capital LLC |
10171 |
19.4‰ |
| BALYASNY ASSET MANAGEMENT L.P. |
10037 |
19.2‰ |
| Janney Montgomery Scott LLC |
10000 |
19.1‰ |
| Qube Research & Technologies Ltd |
9046 |
17.3‰ |
| CITIGROUP INC |
7429 |
14.2‰ |
| Russell Investments Group, Ltd. |
6690 |
12.8‰ |
| SIMPLEX TRADING, LLC |
5309 |
10.1‰ |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
5199 |
9.9‰ |
| BNP PARIBAS FINANCIAL MARKETS |
5004 |
9.6‰ |
| GROUP ONE TRADING LLC |
3935 |
7.5‰ |
| Legal & General Group Plc |
2747 |
5.2‰ |
| Ameritas Investment Partners, Inc. |
2568 |
4.9‰ |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
2364 |
4.5‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
1631 |
3.1‰ |
| AMALGAMATED BANK |
1154 |
2.2‰ |
| Activest Wealth Management |
1001 |
1.9‰ |
| Eagle Bay Advisors LLC |
582 |
1.1‰ |
| Avion Wealth |
352 |
0.7‰ |
| PNC FINANCIAL SERVICES GROUP, INC. |
199 |
0.4‰ |
| NISA INVESTMENT ADVISORS, LLC |
48 |
0.1‰ |
| CWM, LLC |
21 |
< 0.1‰ |
| WEST PACES ADVISORS INC. |
12 |
< 0.1‰ |
| INNEALTA CAPITAL, LLC |
10 |
< 0.1‰ |
| EverSource Wealth Advisors, LLC |
7 |
< 0.1‰ |
| Global Retirement Partners, LLC |
6 |
< 0.1‰ |
| MATHER GROUP, LLC. |
4 |
< 0.1‰ |
