| BVF INC/IL |
16552417 |
19.2% |
| NEA Management Company, LLC |
6147260 |
7.1% |
| Deep Track Capital, LP |
5000000 |
5.8% |
| FMR LLC |
4684624 |
5.4% |
| VANGUARD GROUP INC |
3514345 |
4.1% |
| MILLENNIUM MANAGEMENT LLC |
3423095 |
4.0% |
| Redmile Group, LLC |
3077828 |
3.6% |
| Vivo Capital, LLC |
2988000 |
3.5% |
| Logos Global Management LP |
2900000 |
3.4% |
| Opaleye Management Inc. |
2780000 |
3.2% |
| CITADEL ADVISORS LLC |
2506402 |
2.9% |
| MORGAN STANLEY |
1774573 |
2.1% |
| ACADIAN ASSET MANAGEMENT LLC |
1762814 |
2.0% |
| BlackRock, Inc. |
1440316 |
1.7% |
| BlackRock Finance, Inc. |
1267129 |
1.5% |
| Rock Springs Capital Management LP |
1200409 |
1.4% |
| BARCLAYS PLC |
1134018 |
1.3% |
| PLATINUM INVESTMENT MANAGEMENT LTD |
1060139 |
1.2% |
| Ikarian Capital, LLC |
972675 |
1.1% |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
936797 |
1.1% |
| DEUTSCHE BANK AG\ |
913039 |
1.1% |
| GEODE CAPITAL MANAGEMENT, LLC |
907408 |
1.1% |
| GSA CAPITAL PARTNERS LLP |
710146 |
0.8% |
| ExodusPoint Capital Management, LP |
698798 |
0.8% |
| Checkpoint Capital L.P. |
649957 |
0.8% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
620457 |
0.7% |
| Walleye Capital LLC |
575518 |
0.7% |
| RENAISSANCE TECHNOLOGIES LLC |
562411 |
0.7% |
| NORTHERN TRUST CORP |
540248 |
0.6% |
| D. E. Shaw & Co., Inc. |
368957 |
0.4% |
| RBF Capital, LLC |
350000 |
0.4% |
| MPM BioImpact LLC |
344900 |
0.4% |
| GOLDMAN SACHS GROUP INC |
343668 |
0.4% |
| BANK OF AMERICA CORP /DE/ |
307253 |
0.4% |
| BOOTHBAY FUND MANAGEMENT, LLC |
264102 |
0.3% |
| STATE STREET CORP |
247975 |
0.3% |
| Pennant Investors, LP |
186100 |
0.2% |
| JANE STREET GROUP, LLC |
181412 |
0.2% |
| Samsara BioCapital, LLC |
172089 |
0.2% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
167400 |
0.2% |
| Centiva Capital, LP |
136800 |
0.2% |
| DIMENSIONAL FUND ADVISORS LP |
126642 |
0.1% |
| GROUP ONE TRADING LLC |
118153 |
0.1% |
| JPMORGAN CHASE & CO |
81187 |
0.1% |
| Paloma Partners Management Co |
78995 |
0.1% |
| Amundi |
75686 |
0.1% |
| Wilshire Advisors LLC |
75055 |
0.1% |
| BLAIR WILLIAM & CO/IL |
64817 |
0.1% |
| ADAR1 Capital Management, LLC |
62264 |
0.1% |
| Cubist Systematic Strategies, LLC |
55486 |
0.1% |
| CITIGROUP INC |
42160 |
48.9‰ |
| RHUMBLINE ADVISERS |
38096 |
44.2‰ |
| HSBC HOLDINGS PLC |
35830 |
41.5‰ |
| TWO SIGMA ADVISERS, LP |
35100 |
40.7‰ |
| Graham Capital Management, L.P. |
33270 |
38.6‰ |
| Schonfeld Strategic Advisors LLC |
32800 |
38.0‰ |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29756 |
34.5‰ |
| HRT FINANCIAL LP |
29328 |
34.0‰ |
| EASTERLY INVESTMENT PARTNERS LLC |
25000 |
29.0‰ |
| PRELUDE CAPITAL MANAGEMENT, LLC |
25000 |
29.0‰ |
| Vanguard Personalized Indexing Management, LLC |
22672 |
26.3‰ |
| Comprehensive Financial Management LLC |
20015 |
23.2‰ |
| UBS Group AG |
18443 |
21.4‰ |
| BALYASNY ASSET MANAGEMENT L.P. |
15654 |
18.1‰ |
| Tower Research Capital LLC (TRC) |
15294 |
17.7‰ |
| Blackstone Inc. |
14943 |
17.3‰ |
| COMMONWEALTH EQUITY SERVICES, LLC |
12889 |
14.9‰ |
| Zurcher Kantonalbank (Zurich Cantonalbank) |
11388 |
13.2‰ |
| CERTUITY, LLC |
11356 |
13.2‰ |
| Douglas Lane & Associates, LLC |
10051 |
11.7‰ |
| FEDERATED HERMES, INC. |
8671 |
10.1‰ |
| Russell Investments Group, Ltd. |
4213 |
4.9‰ |
| MACQUARIE GROUP LTD |
3422 |
4.0‰ |
| Steward Partners Investment Advisory, LLC |
1500 |
1.7‰ |
| BNP PARIBAS FINANCIAL MARKETS |
981 |
1.1‰ |
| Parallel Advisors, LLC |
770 |
0.9‰ |
| WELLS FARGO & COMPANY/MN |
600 |
0.7‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
566 |
0.7‰ |
| SIMPLEX TRADING, LLC |
501 |
0.6‰ |
| EverSource Wealth Advisors, LLC |
477 |
0.6‰ |
| CWM, LLC |
389 |
0.5‰ |
| NISA INVESTMENT ADVISORS, LLC |
345 |
0.4‰ |
| SRS Capital Advisors, Inc. |
159 |
0.2‰ |
| OSAIC HOLDINGS, INC. |
70 |
0.1‰ |
| Farther Finance Advisors, LLC |
61 |
0.1‰ |
| NewEdge Advisors, LLC |
47 |
0.1‰ |
| INNEALTA CAPITAL, LLC |
26 |
< 0.1‰ |
