| BAKER BROS. ADVISORS LP |
42877916 |
26.3% |
| VANGUARD GROUP INC |
13712131 |
8.4% |
| RTW INVESTMENTS, LP |
13707506 |
8.4% |
| BlackRock, Inc. |
12729859 |
7.8% |
| BlackRock Finance, Inc. |
12062213 |
7.4% |
| STATE STREET CORP |
5800790 |
3.6% |
| Point72 Asset Management, L.P. |
3710140 |
2.3% |
| MILLENNIUM MANAGEMENT LLC |
2937714 |
1.8% |
| D. E. Shaw & Co., Inc. |
2934926 |
1.8% |
| GEODE CAPITAL MANAGEMENT, LLC |
2844714 |
1.7% |
| MARSHALL WACE, LLP |
2774353 |
1.7% |
| FRED ALGER MANAGEMENT, LLC |
2704439 |
1.7% |
| Palo Alto Investors LP |
2418841 |
1.5% |
| MORGAN STANLEY |
2391105 |
1.5% |
| FMR LLC |
2366976 |
1.5% |
| FIRST TRUST ADVISORS LP |
2068320 |
1.3% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
1601216 |
1.0% |
| TANG CAPITAL MANAGEMENT LLC |
1500000 |
0.9% |
| NORGES BANK |
1451483 |
0.9% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
1355002 |
0.8% |
| EcoR1 Capital, LLC |
1346475 |
0.8% |
| GOLDMAN SACHS GROUP INC |
1340944 |
0.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
1275279 |
0.8% |
| Connor, Clark & Lunn Investment Management Ltd. |
1253542 |
0.8% |
| DEUTSCHE BANK AG\ |
1242194 |
0.8% |
| NORTHERN TRUST CORP |
1144758 |
0.7% |
| Qube Research & Technologies Ltd |
1105106 |
0.7% |
| JUPITER ASSET MANAGEMENT LTD |
1060840 |
0.7% |
| Rockefeller Capital Management L.P. |
954250 |
0.6% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
920086 |
0.6% |
| CAPITAL FUND MANAGEMENT S.A. |
916609 |
0.6% |
| Finepoint Capital LP |
905384 |
0.6% |
| EMERALD ADVISERS, LLC |
808831 |
0.5% |
| BALYASNY ASSET MANAGEMENT L.P. |
772146 |
0.5% |
| RICE HALL JAMES & ASSOCIATES, LLC |
742935 |
0.5% |
| AMERIPRISE FINANCIAL INC |
742646 |
0.5% |
| CANADA PENSION PLAN INVESTMENT BOARD |
738700 |
0.5% |
| BANK OF AMERICA CORP /DE/ |
695518 |
0.4% |
| Cubist Systematic Strategies, LLC |
666578 |
0.4% |
| PANAGORA ASSET MANAGEMENT INC |
661870 |
0.4% |
| CITADEL ADVISORS LLC |
653768 |
0.4% |
| DIMENSIONAL FUND ADVISORS LP |
649150 |
0.4% |
| JPMORGAN CHASE & CO |
628249 |
0.4% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
558849 |
0.3% |
| ALGERT GLOBAL LLC |
534143 |
0.3% |
| Bank of New York Mellon Corp |
525566 |
0.3% |
| Pictet Asset Management Holding SA |
512690 |
0.3% |
| JANE STREET GROUP, LLC |
498225 |
0.3% |
| RENAISSANCE TECHNOLOGIES LLC |
476000 |
0.3% |
| Frazier Life Sciences Management, L.P. |
470338 |
0.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
462078 |
0.3% |
| UBS Group AG |
455551 |
0.3% |
| Nuveen Asset Management, LLC |
441849 |
0.3% |
| Hudson Bay Capital Management LP |
387500 |
0.2% |
| TWO SIGMA INVESTMENTS, LP |
347717 |
0.2% |
| SPHERA FUNDS MANAGEMENT LTD. |
327539 |
0.2% |
| Russell Investments Group, Ltd. |
316094 |
0.2% |
| Rafferty Asset Management, LLC |
305079 |
0.2% |
| Trexquant Investment LP |
301678 |
0.2% |
| WCM INVESTMENT MANAGEMENT, LLC |
289417 |
0.2% |
| BNP PARIBAS FINANCIAL MARKETS |
288471 |
0.2% |
| NORDEA INVESTMENT MANAGEMENT AB |
275485 |
0.2% |
| Birchview Capital, LP |
250400 |
0.2% |
| STATE OF WISCONSIN INVESTMENT BOARD |
242634 |
0.1% |
| Erste Asset Management GmbH |
242300 |
0.1% |
| Ghost Tree Capital, LLC |
225000 |
0.1% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
219125 |
0.1% |
| Swiss National Bank |
210604 |
0.1% |
| Neo Ivy Capital Management |
203048 |
0.1% |
| FRANKLIN RESOURCES INC |
189192 |
0.1% |
| RHUMBLINE ADVISERS |
186500 |
0.1% |
| WELLS FARGO & COMPANY/MN |
185717 |
0.1% |
| GSA CAPITAL PARTNERS LLP |
180700 |
0.1% |
| HRT FINANCIAL LP |
175819 |
0.1% |
| Fisher Asset Management, LLC |
162619 |
0.1% |
| Empire Life Investments Inc. |
160662 |
0.1% |
| HOHIMER WEALTH MANAGEMENT, LLC |
159133 |
0.1% |
| Hillsdale Investment Management Inc. |
152528 |
0.1% |
| Privium Fund Management B.V. |
148400 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
147480 |
0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
132862 |
0.1% |
| Legal & General Group Plc |
132706 |
0.1% |
| ALPS ADVISORS INC |
128866 |
0.1% |
| BARCLAYS PLC |
122711 |
0.1% |
| Allspring Global Investments Holdings, LLC |
108838 |
0.1% |
| Engineers Gate Manager LP |
107745 |
0.1% |
| ENVESTNET ASSET MANAGEMENT INC |
107543 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
105576 |
0.1% |
| Walleye Capital LLC |
103830 |
0.1% |
| Nan Fung Group Holdings Ltd |
102984 |
0.1% |
| Hennion & Walsh Asset Management, Inc. |
102477 |
0.1% |
| TUDOR INVESTMENT CORP ET AL |
101972 |
0.1% |
| Nebula Research & Development LLC |
100278 |
0.1% |
| AlphaCentric Advisors LLC |
100000 |
0.1% |
| SG Americas Securities, LLC |
99476 |
0.1% |
| DekaBank Deutsche Girozentrale |
97284 |
0.1% |
| BANK OF MONTREAL /CAN/ |
96225 |
0.1% |
| VICTORY CAPITAL MANAGEMENT INC |
94422 |
0.1% |
| MACQUARIE GROUP LTD |
92648 |
0.1% |
| Van Hulzen Asset Management, LLC |
91485 |
0.1% |
