| RA CAPITAL MANAGEMENT, L.P. |
10108400 |
18.0% |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
4962824 |
8.8% |
| FMR LLC |
4922555 |
8.8% |
| Artisan Partners Limited Partnership |
4295029 |
7.7% |
| Avoro Capital Advisors LLC |
4196661 |
7.5% |
| JANUS HENDERSON GROUP PLC |
3918813 |
7.0% |
| WELLINGTON MANAGEMENT GROUP LLP |
2612856 |
4.7% |
| Capital International Investors |
2104298 |
3.7% |
| FRANKLIN RESOURCES INC |
2084851 |
3.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1784148 |
3.2% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
1711015 |
3.0% |
| Invesco Ltd. |
1106449 |
2.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
820512 |
1.5% |
| Sofinnova Investments, Inc. |
734284 |
1.3% |
| Paradigm Biocapital Advisors LP |
664307 |
1.2% |
| Spyglass Capital Management LLC |
662888 |
1.2% |
| AMERIPRISE FINANCIAL INC |
660662 |
1.2% |
| BlackRock, Inc. |
653288 |
1.2% |
| TimesSquare Capital Management, LLC |
596314 |
1.1% |
| CITADEL ADVISORS LLC |
537762 |
1.0% |
| BROWN ADVISORY INC |
478676 |
0.9% |
| ALLIANCEBERNSTEIN L.P. |
475001 |
0.8% |
| MILLENNIUM MANAGEMENT LLC |
473449 |
0.8% |
| FIL Ltd |
442508 |
0.8% |
| GOLDMAN SACHS GROUP INC |
421551 |
0.8% |
| BlackRock Finance, Inc. |
405989 |
0.7% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
346218 |
0.6% |
| FRED ALGER MANAGEMENT, LLC |
307073 |
0.5% |
| AMERICAN CENTURY COMPANIES INC |
305974 |
0.5% |
| Siren, L.L.C. |
297321 |
0.5% |
| Rock Springs Capital Management LP |
290000 |
0.5% |
| D. E. Shaw & Co., Inc. |
281537 |
0.5% |
| SEI INVESTMENTS CO |
264571 |
0.5% |
| TWO SIGMA INVESTMENTS, LP |
255320 |
0.5% |
| ARS Investment Partners, LLC |
253139 |
0.5% |
| BANK OF AMERICA CORP /DE/ |
246961 |
0.4% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
233673 |
0.4% |
| Tri Locum Partners LP |
227762 |
0.4% |
| Q Global Advisors, LLC |
219459 |
0.4% |
| TWO SIGMA ADVISERS, LP |
202000 |
0.4% |
| NEW YORK STATE COMMON RETIREMENT FUND |
199401 |
0.4% |
| Woodline Partners LP |
198766 |
0.4% |
| Candriam S.C.A. |
195347 |
0.3% |
| Finepoint Capital LP |
189272 |
0.3% |
| First Turn Management, LLC |
186581 |
0.3% |
| DEUTSCHE BANK AG\ |
181029 |
0.3% |
| Allspring Global Investments Holdings, LLC |
179252 |
0.3% |
| MORGAN STANLEY |
166969 |
0.3% |
| BNP Paribas Asset Management Holding S.A. |
163110 |
0.3% |
| abrdn plc |
160602 |
0.3% |
| RICE HALL JAMES & ASSOCIATES, LLC |
151656 |
0.3% |
| Pictet Asset Management Holding SA |
146327 |
0.3% |
| ACADIAN ASSET MANAGEMENT LLC |
142165 |
0.3% |
| VICTORY CAPITAL MANAGEMENT INC |
134409 |
0.2% |
| LOOMIS SAYLES & CO L P |
121594 |
0.2% |
| Saturn V Capital Management LP |
113224 |
0.2% |
| Bank of New York Mellon Corp |
110641 |
0.2% |
| Artal Group S.A. |
101100 |
0.2% |
| BNP PARIBAS FINANCIAL MARKETS |
100023 |
0.2% |
| SOROS FUND MANAGEMENT LLC |
100000 |
0.2% |
| TD ASSET MANAGEMENT INC |
99946 |
0.2% |
| Schonfeld Strategic Advisors LLC |
98141 |
0.2% |
| Ghost Tree Capital, LLC |
86721 |
0.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
81396 |
0.1% |
| DAFNA Capital Management LLC |
80972 |
0.1% |
| THRIVENT FINANCIAL FOR LUTHERANS |
78245 |
0.1% |
| ADAR1 Capital Management, LLC |
71402 |
0.1% |
| BAILLIE GIFFORD & CO |
71071 |
0.1% |
| JPMORGAN CHASE & CO |
65262 |
0.1% |
| Alyeska Investment Group, L.P. |
60000 |
0.1% |
| GEODE CAPITAL MANAGEMENT, LLC |
57786 |
0.1% |
| Qube Research & Technologies Ltd |
54748 |
0.1% |
| HARBOR CAPITAL ADVISORS, INC. |
52200 |
0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
47712 |
0.1% |
| Resolute Capital Asset Partners LLC |
47000 |
0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
44918 |
0.1% |
| First Light Asset Management, LLC |
36157 |
0.1% |
| STATE STREET CORP |
35057 |
0.1% |
| Matisse Capital |
34729 |
0.1% |
| TUDOR INVESTMENT CORP ET AL |
33375 |
0.1% |
| T. Rowe Price Investment Management, Inc. |
30564 |
0.1% |
| Neuberger Berman Group LLC |
30296 |
0.1% |
| MARSHALL WACE, LLP |
30289 |
0.1% |
| DekaBank Deutsche Girozentrale |
30000 |
0.1% |
| CITIGROUP INC |
25281 |
45.0‰ |
| Evolutionary Tree Capital Management, LLC |
24862 |
44.3‰ |
| Henry James International Management Inc. |
24497 |
43.6‰ |
| Trexquant Investment LP |
23697 |
42.2‰ |
| Nicholas Investment Partners, LP |
23216 |
41.4‰ |
| Erste Asset Management GmbH |
20300 |
36.2‰ |
| Lighthouse Investment Partners, LLC |
20250 |
36.1‰ |
| Cinctive Capital Management LP |
19350 |
34.5‰ |
| BARCLAYS PLC |
19004 |
33.9‰ |
| VOYA INVESTMENT MANAGEMENT LLC |
17655 |
31.5‰ |
| Campbell & CO Investment Adviser LLC |
17260 |
30.7‰ |
| JANE STREET GROUP, LLC |
16261 |
29.0‰ |
| UBS Group AG |
15921 |
28.4‰ |
| SEVEN EIGHT CAPITAL, LP |
15876 |
28.3‰ |
| Parkwood LLC |
13696 |
24.4‰ |
| Nan Fung Group Holdings Ltd |
13600 |
24.2‰ |
