| BAKER BROS. ADVISORS LP |
30738524 |
13.6% |
| BlackRock Finance, Inc. |
21356274 |
9.5% |
| VANGUARD GROUP INC |
20375447 |
9.0% |
| BlackRock, Inc. |
16510467 |
7.3% |
| DODGE & COX |
15279343 |
6.8% |
| STATE STREET CORP |
10851519 |
4.8% |
| RENAISSANCE TECHNOLOGIES LLC |
5218337 |
2.3% |
| GEODE CAPITAL MANAGEMENT, LLC |
4046638 |
1.8% |
| Invesco Ltd. |
3569557 |
1.6% |
| ACADIAN ASSET MANAGEMENT LLC |
3560989 |
1.6% |
| LSV ASSET MANAGEMENT |
2769892 |
1.2% |
| Pacer Advisors, Inc. |
2692182 |
1.2% |
| AQR CAPITAL MANAGEMENT LLC |
2661758 |
1.2% |
| MORGAN STANLEY |
2254474 |
1.0% |
| Bellevue Group AG |
2153504 |
1.0% |
| NORGES BANK |
2124167 |
0.9% |
| Legal & General Group Plc |
1868130 |
0.8% |
| NORTHERN TRUST CORP |
1813119 |
0.8% |
| FMR LLC |
1787408 |
0.8% |
| ARMISTICE CAPITAL, LLC |
1764000 |
0.8% |
| KBC Group NV |
1724410 |
0.8% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1536238 |
0.7% |
| JANE STREET GROUP, LLC |
1490359 |
0.7% |
| Candriam S.C.A. |
1319681 |
0.6% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
1245051 |
0.6% |
| FIRST TRUST ADVISORS LP |
1244048 |
0.6% |
| HSBC HOLDINGS PLC |
1240952 |
0.6% |
| D. E. Shaw & Co., Inc. |
1233217 |
0.5% |
| Robeco Institutional Asset Management B.V. |
1195370 |
0.5% |
| DIMENSIONAL FUND ADVISORS LP |
1181269 |
0.5% |
| Woodline Partners LP |
1154214 |
0.5% |
| Bank of New York Mellon Corp |
1147951 |
0.5% |
| Connor, Clark & Lunn Investment Management Ltd. |
1129981 |
0.5% |
| GOLDMAN SACHS GROUP INC |
948736 |
0.4% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
908576 |
0.4% |
| BARCLAYS PLC |
894390 |
0.4% |
| Allspring Global Investments Holdings, LLC |
892710 |
0.4% |
| FEDERATED HERMES, INC. |
858147 |
0.4% |
| GLENMEDE TRUST CO NA |
853987 |
0.4% |
| CITADEL ADVISORS LLC |
821669 |
0.4% |
| DEUTSCHE BANK AG\ |
798048 |
0.4% |
| Man Group plc |
786566 |
0.3% |
| APG Asset Management N.V. |
783288 |
0.3% |
| AMERIPRISE FINANCIAL INC |
767073 |
0.3% |
| Pictet Asset Management Holding SA |
752716 |
0.3% |
| BANK OF AMERICA CORP /DE/ |
718744 |
0.3% |
| Amundi |
699717 |
0.3% |
| CANADA PENSION PLAN INVESTMENT BOARD |
645889 |
0.3% |
| Russell Investments Group, Ltd. |
625880 |
0.3% |
| Schonfeld Strategic Advisors LLC |
624524 |
0.3% |
| Grantham, Mayo, Van Otterloo & Co. LLC |
585712 |
0.3% |
| Swedbank AB |
567424 |
0.3% |
| Avidity Partners Management LP |
529000 |
0.2% |
| Applied Finance Capital Management, LLC |
499760 |
0.2% |
| JPMORGAN CHASE & CO |
494223 |
0.2% |
| Swiss National Bank |
478774 |
0.2% |
| HRT FINANCIAL LP |
473258 |
0.2% |
| Nuveen Asset Management, LLC |
461684 |
0.2% |
| UBS Group AG |
450853 |
0.2% |
| Sumitomo Mitsui Trust Group, Inc. |
447342 |
0.2% |
| MILLENNIUM MANAGEMENT LLC |
420302 |
0.2% |
| WORLDQUANT MILLENNIUM ADVISORS LLC |
408051 |
0.2% |
| ARK Investment Management LLC |
398663 |
0.2% |
| Capital World Investors |
396000 |
0.2% |
| MACKENZIE FINANCIAL CORP |
381704 |
0.2% |
| TODD ASSET MANAGEMENT LLC |
380770 |
0.2% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
373976 |
0.2% |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
370411 |
0.2% |
| RHUMBLINE ADVISERS |
363221 |
0.2% |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC |
334793 |
0.1% |
| BNP PARIBAS FINANCIAL MARKETS |
324403 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
314787 |
0.1% |
| Rafferty Asset Management, LLC |
303084 |
0.1% |
| CITIGROUP INC |
291185 |
0.1% |
| FRANKLIN RESOURCES INC |
251906 |
0.1% |
| VICTORY CAPITAL MANAGEMENT INC |
251780 |
0.1% |
| Mitsubishi UFJ Asset Management Co., Ltd. |
248875 |
0.1% |
| PRINCIPAL FINANCIAL GROUP INC |
247888 |
0.1% |
| Andra AP-fonden |
247800 |
0.1% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
246585 |
0.1% |
| ASHFORD CAPITAL MANAGEMENT INC |
244770 |
0.1% |
| AMERICAN CENTURY COMPANIES INC |
240603 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
239138 |
0.1% |
| CAPITAL FUND MANAGEMENT S.A. |
234807 |
0.1% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
225413 |
0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
225112 |
0.1% |
| Qube Research & Technologies Ltd |
221755 |
0.1% |
| Hudson Bay Capital Management LP |
219300 |
0.1% |
| TWO SIGMA INVESTMENTS, LP |
218083 |
0.1% |
| BANK OF MONTREAL /CAN/ |
217886 |
0.1% |
| Mitsubishi UFJ Trust & Banking Corp |
214183 |
0.1% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
211984 |
0.1% |
| Illinois Municipal Retirement Fund |
210399 |
0.1% |
| HighTower Advisors, LLC |
210372 |
0.1% |
| Skandinaviska Enskilda Banken AB (publ) |
204910 |
0.1% |
| SECTOR GAMMA AS |
203376 |
0.1% |
| STEMPOINT CAPITAL LP |
193623 |
0.1% |
| GRIMES & COMPANY, INC. |
192295 |
0.1% |
| AXA S.A. |
188835 |
0.1% |
| ROYAL LONDON ASSET MANAGEMENT LTD |
182852 |
0.1% |
