| Redmile Group, LLC |
13169057 |
13.4% |
| BlackRock, Inc. |
10941582 |
11.2% |
| VANGUARD GROUP INC |
10569814 |
10.8% |
| BlackRock Finance, Inc. |
10116106 |
10.3% |
| Boxer Capital, LLC |
8215910 |
8.4% |
| Deep Track Capital, LP |
5572607 |
5.7% |
| STATE STREET CORP |
5338689 |
5.4% |
| Bellevue Group AG |
4839779 |
4.9% |
| CITADEL ADVISORS LLC |
4488026 |
4.6% |
| D. E. Shaw & Co., Inc. |
4077922 |
4.2% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) |
3555871 |
3.6% |
| JOHNSON & JOHNSON |
3379064 |
3.4% |
| MORGAN STANLEY |
3147989 |
3.2% |
| BAKER BROS. ADVISORS LP |
2997772 |
3.1% |
| Assenagon Asset Management S.A. |
2574703 |
2.6% |
| GOLDMAN SACHS GROUP INC |
2348554 |
2.4% |
| GEODE CAPITAL MANAGEMENT, LLC |
2247383 |
2.3% |
| DIMENSIONAL FUND ADVISORS LP |
2130280 |
2.2% |
| ACADIAN ASSET MANAGEMENT LLC |
2008862 |
2.0% |
| BANK OF AMERICA CORP /DE/ |
1985732 |
2.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
1694217 |
1.7% |
| JPMORGAN CHASE & CO |
1554224 |
1.6% |
| TWO SIGMA ADVISERS, LP |
1523500 |
1.6% |
| ORBIMED ADVISORS LLC |
1355352 |
1.4% |
| Artal Group S.A. |
1032500 |
1.1% |
| FEDERATED HERMES, INC. |
1031505 |
1.1% |
| TWO SIGMA INVESTMENTS, LP |
1019987 |
1.0% |
| Woodline Partners LP |
1002002 |
1.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
879375 |
0.9% |
| Soleus Capital Management, L.P. |
870000 |
0.9% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
870000 |
0.9% |
| Integral Health Asset Management, LLC |
850000 |
0.9% |
| NORTHERN TRUST CORP |
736674 |
0.8% |
| TANG CAPITAL MANAGEMENT LLC |
700000 |
0.7% |
| RENAISSANCE TECHNOLOGIES LLC |
548544 |
0.6% |
| Octagon Capital Advisors LP |
520800 |
0.5% |
| GCM Grosvenor Holdings, LLC |
495916 |
0.5% |
| MILLENNIUM MANAGEMENT LLC |
446668 |
0.5% |
| Bank of New York Mellon Corp |
374132 |
0.4% |
| PRUDENTIAL FINANCIAL INC |
356101 |
0.4% |
| PERCEPTIVE ADVISORS LLC |
345575 |
0.4% |
| MARSHALL WACE, LLP |
330082 |
0.3% |
| Campbell & CO Investment Adviser LLC |
324585 |
0.3% |
| Nuveen Asset Management, LLC |
324004 |
0.3% |
| Bruce & Co., Inc. |
300000 |
0.3% |
| BNP PARIBAS FINANCIAL MARKETS |
287711 |
0.3% |
| Monaco Asset Management SAM |
286900 |
0.3% |
| GSA CAPITAL PARTNERS LLP |
264467 |
0.3% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
262414 |
0.3% |
| Rafferty Asset Management, LLC |
250793 |
0.3% |
| AMERIPRISE FINANCIAL INC |
242432 |
0.2% |
| FRANKLIN RESOURCES INC |
229863 |
0.2% |
| JANE STREET GROUP, LLC |
217739 |
0.2% |
| FMR LLC |
181089 |
0.2% |
| Swiss National Bank |
179100 |
0.2% |
| CAXTON ASSOCIATES LP |
172863 |
0.2% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
167055 |
0.2% |
| AMERICAN CENTURY COMPANIES INC |
166255 |
0.2% |
| UBS Group AG |
164356 |
0.2% |
| RHUMBLINE ADVISERS |
160001 |
0.2% |
| ALLIANCEBERNSTEIN L.P. |
146580 |
0.1% |
| Pennant Investors, LP |
146100 |
0.1% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
139366 |
0.1% |
| CANADA PENSION PLAN INVESTMENT BOARD |
132700 |
0.1% |
| BARCLAYS PLC |
122888 |
0.1% |
| VICTORY CAPITAL MANAGEMENT INC |
104019 |
0.1% |
| Legal & General Group Plc |
103029 |
0.1% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
102295 |
0.1% |
| Invesco Ltd. |
102096 |
0.1% |
| Russell Investments Group, Ltd. |
101933 |
0.1% |
| THRIVENT FINANCIAL FOR LUTHERANS |
100566 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
89653 |
0.1% |
| HSBC HOLDINGS PLC |
88514 |
0.1% |
| WELLINGTON MANAGEMENT GROUP LLP |
75161 |
0.1% |
| Leo Wealth, LLC |
70439 |
0.1% |
| Institute for Wealth Management, LLC. |
66886 |
0.1% |
| ALGERT GLOBAL LLC |
65611 |
0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
65219 |
0.1% |
| MetLife Investment Management, LLC |
59989 |
0.1% |
| HRT FINANCIAL LP |
59026 |
0.1% |
| Nebula Research & Development LLC |
58365 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
57281 |
0.1% |
| WELLS FARGO & COMPANY/MN |
57252 |
0.1% |
| CITIGROUP INC |
47869 |
48.8‰ |
| NEOS Investment Management LLC |
47468 |
48.4‰ |
| PROFUND ADVISORS LLC |
46528 |
47.4‰ |
| TUDOR INVESTMENT CORP ET AL |
45290 |
46.2‰ |
| CORNERCAP INVESTMENT COUNSEL INC |
43472 |
44.3‰ |
| STIFEL FINANCIAL CORP |
41487 |
42.3‰ |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
39715 |
40.5‰ |
| Verition Fund Management LLC |
36675 |
37.4‰ |
| SG Americas Securities, LLC |
36372 |
37.1‰ |
| Qube Research & Technologies Ltd |
35134 |
35.8‰ |
| MARTINGALE ASSET MANAGEMENT L P |
34797 |
35.5‰ |
| XTX Topco Ltd |
33898 |
34.6‰ |
| DEUTSCHE BANK AG\ |
33453 |
34.1‰ |
| VOYA INVESTMENT MANAGEMENT LLC |
33254 |
33.9‰ |
| Point72 (DIFC) Ltd |
31682 |
32.3‰ |
| EXCHANGE TRADED CONCEPTS, LLC |
30059 |
30.7‰ |
| SHERBROOKE PARK ADVISERS LLC |
28652 |
29.2‰ |
