| BAKER BROS. ADVISORS LP |
4090316 |
8.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
4075091 |
8.4% |
| Artal Group S.A. |
3330422 |
6.9% |
| Siren, L.L.C. |
3330422 |
6.9% |
| Redmile Group, LLC |
3072478 |
6.3% |
| GOLDMAN SACHS GROUP INC |
1333913 |
2.8% |
| BlackRock, Inc. |
1054028 |
2.2% |
| BlackRock Finance, Inc. |
883081 |
1.8% |
| VANGUARD GROUP INC |
878621 |
1.8% |
| FMR LLC |
818873 |
1.7% |
| STATE STREET CORP |
457616 |
0.9% |
| MILLENNIUM MANAGEMENT LLC |
391213 |
0.8% |
| GEODE CAPITAL MANAGEMENT, LLC |
367681 |
0.8% |
| Rhenman & Partners Asset Management AB |
195000 |
0.4% |
| TD ASSET MANAGEMENT INC |
164472 |
0.3% |
| Samsara BioCapital, LLC |
154664 |
0.3% |
| NORTHERN TRUST CORP |
134727 |
0.3% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
132330 |
0.3% |
| D. E. Shaw & Co., Inc. |
131065 |
0.3% |
| MORGAN STANLEY |
111511 |
0.2% |
| RENAISSANCE TECHNOLOGIES LLC |
108693 |
0.2% |
| MARSHALL WACE, LLP |
107267 |
0.2% |
| Bruce & Co., Inc. |
100000 |
0.2% |
| Woodline Partners LP |
75000 |
0.2% |
| ExodusPoint Capital Management, LP |
71503 |
0.1% |
| WELLINGTON MANAGEMENT GROUP LLP |
68965 |
0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
68929 |
0.1% |
| Pennant Investors, LP |
64900 |
0.1% |
| Corton Capital Inc. |
63336 |
0.1% |
| GSA CAPITAL PARTNERS LLP |
61981 |
0.1% |
| Bank of New York Mellon Corp |
53980 |
0.1% |
| TWO SIGMA INVESTMENTS, LP |
50347 |
0.1% |
| Hudson Bay Capital Management LP |
46119 |
0.1% |
| Eagle Bay Advisors LLC |
44635 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
41230 |
0.1% |
| Nuveen Asset Management, LLC |
40749 |
0.1% |
| DIMENSIONAL FUND ADVISORS LP |
37034 |
0.1% |
| Point72 Asset Management, L.P. |
27246 |
0.1% |
| Verition Fund Management LLC |
26120 |
0.1% |
| BANK OF AMERICA CORP /DE/ |
24319 |
0.1% |
| PANAGORA ASSET MANAGEMENT INC |
23406 |
48.4‰ |
| RHUMBLINE ADVISERS |
22726 |
47.0‰ |
| EXCHANGE TRADED CONCEPTS, LLC |
21307 |
44.0‰ |
| XTX Topco Ltd |
20408 |
42.2‰ |
| AMERICAN CENTURY COMPANIES INC |
16798 |
34.7‰ |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
16028 |
33.1‰ |
| TUDOR INVESTMENT CORP ET AL |
14537 |
30.0‰ |
| BARCLAYS PLC |
14527 |
30.0‰ |
| Susquehanna Portfolio Strategies, LLC |
14385 |
29.7‰ |
| JANE STREET GROUP, LLC |
13743 |
28.4‰ |
| AQR CAPITAL MANAGEMENT LLC |
12230 |
25.3‰ |
| Virtus ETF Advisers LLC |
11401 |
23.6‰ |
| DEUTSCHE BANK AG\ |
10849 |
22.4‰ |
| CAPTRUST FINANCIAL ADVISORS |
10200 |
21.1‰ |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
8706 |
18.0‰ |
| UBS Group AG |
8407 |
17.4‰ |
| JPMORGAN CHASE & CO |
7073 |
14.6‰ |
| BNP PARIBAS FINANCIAL MARKETS |
6634 |
13.7‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
6512 |
13.5‰ |
| WELLS FARGO & COMPANY/MN |
5133 |
10.6‰ |
| NISA INVESTMENT ADVISORS, LLC |
3906 |
8.1‰ |
| Tower Research Capital LLC (TRC) |
3628 |
7.5‰ |
| CITIGROUP INC |
3320 |
6.9‰ |
| Cubist Systematic Strategies, LLC |
3300 |
6.8‰ |
| CITADEL ADVISORS LLC |
1979 |
4.1‰ |
| Legal & General Group Plc |
1361 |
2.8‰ |
| Ameritas Investment Partners, Inc. |
1327 |
2.7‰ |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
1099 |
2.3‰ |
| SIMPLEX TRADING, LLC |
759 |
1.6‰ |
| Russell Investments Group, Ltd. |
737 |
1.5‰ |
| Point72 (DIFC) Ltd |
697 |
1.4‰ |
| COMERICA BANK |
617 |
1.3‰ |
| NBC SECURITIES, INC. |
500 |
1.0‰ |
| AMALGAMATED BANK |
351 |
0.7‰ |
| Quarry LP |
197 |
0.4‰ |
| SIGNATUREFD, LLC |
191 |
0.4‰ |
| OSAIC HOLDINGS, INC. |
59 |
0.1‰ |
| PNC FINANCIAL SERVICES GROUP, INC. |
23 |
< 0.1‰ |
| US BANCORP \DE\ |
17 |
< 0.1‰ |
| Farther Finance Advisors, LLC |
9 |
< 0.1‰ |
| CWM, LLC |
9 |
< 0.1‰ |
