| PRICE T ROWE ASSOCIATES INC /MD/ |
5598563 |
10.0% |
| FMR LLC |
3527986 |
6.3% |
| Artisan Partners Limited Partnership |
3511078 |
6.2% |
| JANUS HENDERSON GROUP PLC |
2468232 |
4.4% |
| T. Rowe Price Investment Management, Inc. |
1924712 |
3.4% |
| Capital World Investors |
1511494 |
2.7% |
| Avoro Capital Advisors LLC |
1238467 |
2.2% |
| BlackRock, Inc. |
1068950 |
1.9% |
| BlackRock Finance, Inc. |
1011291 |
1.8% |
| MORGAN STANLEY |
819841 |
1.5% |
| Bellevue Group AG |
691874 |
1.2% |
| RTW INVESTMENTS, LP |
654430 |
1.2% |
| CITADEL ADVISORS LLC |
653090 |
1.2% |
| Clearbridge Investments, LLC |
617466 |
1.1% |
| Paradigm Biocapital Advisors LP |
538139 |
1.0% |
| WELLINGTON MANAGEMENT GROUP LLP |
426729 |
0.8% |
| Holocene Advisors, LP |
425614 |
0.8% |
| Deep Track Capital, LP |
400000 |
0.7% |
| SEI INVESTMENTS CO |
381544 |
0.7% |
| Pictet Asset Management Holding SA |
308176 |
0.5% |
| ALKEON CAPITAL MANAGEMENT LLC |
300000 |
0.5% |
| BANK OF AMERICA CORP /DE/ |
290201 |
0.5% |
| BAMCO INC /NY/ |
261478 |
0.5% |
| FEDERATED HERMES, INC. |
254390 |
0.5% |
| AMERICAN CENTURY COMPANIES INC |
254363 |
0.5% |
| JENNISON ASSOCIATES LLC |
236438 |
0.4% |
| Rock Springs Capital Management LP |
229250 |
0.4% |
| EVENTIDE ASSET MANAGEMENT, LLC |
218945 |
0.4% |
| TD ASSET MANAGEMENT INC |
212128 |
0.4% |
| ORBIMED ADVISORS LLC |
209100 |
0.4% |
| Invesco Ltd. |
201472 |
0.4% |
| ARMISTICE CAPITAL, LLC |
200000 |
0.4% |
| Fiera Capital Corp |
165595 |
0.3% |
| DEUTSCHE BANK AG\ |
159607 |
0.3% |
| FRANKLIN RESOURCES INC |
136222 |
0.2% |
| Logos Global Management LP |
135000 |
0.2% |
| Alyeska Investment Group, L.P. |
134935 |
0.2% |
| GOLDMAN SACHS GROUP INC |
123041 |
0.2% |
| NEW YORK STATE COMMON RETIREMENT FUND |
119983 |
0.2% |
| Siren, L.L.C. |
115045 |
0.2% |
| MARSHALL WACE, LLP |
113772 |
0.2% |
| BAKER BROS. ADVISORS LP |
111904 |
0.2% |
| Legal & General Group Plc |
108517 |
0.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
106507 |
0.2% |
| TimesSquare Capital Management, LLC |
100650 |
0.2% |
| Boxer Capital, LLC |
100000 |
0.2% |
| FIRST TRUST ADVISORS LP |
93576 |
0.2% |
| abrdn plc |
91348 |
0.2% |
| Eagle Health Investments LP |
88890 |
0.2% |
| PFM Health Sciences, LP |
86832 |
0.2% |
| Checkpoint Capital L.P. |
82150 |
0.1% |
| First Turn Management, LLC |
79978 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
77757 |
0.1% |
| Tri Locum Partners LP |
74558 |
0.1% |
| Camber Capital Management LP |
72000 |
0.1% |
| PGGM Investments |
64409 |
0.1% |
| Saturn V Capital Management LP |
64196 |
0.1% |
| ENVESTNET ASSET MANAGEMENT INC |
62999 |
0.1% |
| Iron Triangle Partners LP |
61704 |
0.1% |
| Avidity Partners Management LP |
60500 |
0.1% |
| Woodline Partners LP |
56771 |
0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
55435 |
0.1% |
| RAYMOND JAMES & ASSOCIATES |
55111 |
0.1% |
| Finepoint Capital LP |
54028 |
0.1% |
| Candriam S.C.A. |
51418 |
0.1% |
| VAN ECK ASSOCIATES CORP |
50821 |
0.1% |
| WELLS FARGO & COMPANY/MN |
46212 |
0.1% |
| BALYASNY ASSET MANAGEMENT L.P. |
45164 |
0.1% |
| D. E. Shaw & Co., Inc. |
43882 |
0.1% |
| ROYAL LONDON ASSET MANAGEMENT LTD |
41411 |
0.1% |
| THRIVENT FINANCIAL FOR LUTHERANS |
36788 |
0.1% |
| AXA S.A. |
36372 |
0.1% |
| NORTHERN TRUST CORP |
36326 |
0.1% |
| Point72 Asset Management, L.P. |
34728 |
0.1% |
| Eversept Partners, LP |
34593 |
0.1% |
| QVT Financial LP |
32498 |
0.1% |
| Russell Investments Group, Ltd. |
32213 |
0.1% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
28309 |
0.1% |
| PineBridge Investments, L.P. |
27856 |
49.5‰ |
| Handelsbanken Fonder AB |
27418 |
48.8‰ |
| GEODE CAPITAL MANAGEMENT, LLC |
27152 |
48.3‰ |
| CenterBook Partners LP |
25919 |
46.1‰ |
| MOORE CAPITAL MANAGEMENT, LP |
25000 |
44.5‰ |
| AWM Investment Company, Inc. |
25000 |
44.5‰ |
| ExodusPoint Capital Management, LP |
24041 |
42.8‰ |
| Atika Capital Management LLC |
23595 |
42.0‰ |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
20425 |
36.3‰ |
| DCF Advisers, LLC |
20000 |
35.6‰ |
| DIMENSIONAL FUND ADVISORS LP |
19388 |
34.5‰ |
| JANE STREET GROUP, LLC |
19306 |
34.3‰ |
| Erste Asset Management GmbH |
16800 |
29.9‰ |
| Verition Fund Management LLC |
16030 |
28.5‰ |
| NATIXIS ADVISORS, LLC |
15923 |
28.3‰ |
| USS Investment Management Ltd |
15748 |
28.0‰ |
| PERCEPTIVE ADVISORS LLC |
15600 |
27.7‰ |
| Artia Global Partners LP |
15138 |
26.9‰ |
| Hudson Bay Capital Management LP |
15000 |
26.7‰ |
| CANADA LIFE ASSURANCE Co |
14644 |
26.0‰ |
| EFG Asset Management (North America) Corp. |
14506 |
25.8‰ |
| HARVEY CAPITAL MANAGEMENT INC |
14119 |
25.1‰ |
