| WELLINGTON MANAGEMENT GROUP LLP |
16388697 |
14.1% |
| EcoR1 Capital, LLC |
11607425 |
10.0% |
| Avoro Capital Advisors LLC |
11111111 |
9.6% |
| VANGUARD GROUP INC |
9809552 |
8.5% |
| BlackRock, Inc. |
6477989 |
5.6% |
| BlackRock Finance, Inc. |
5795272 |
5.0% |
| STATE STREET CORP |
4146694 |
3.6% |
| T. Rowe Price Investment Management, Inc. |
4048412 |
3.5% |
| JENNISON ASSOCIATES LLC |
3591416 |
3.1% |
| FMR LLC |
3299790 |
2.8% |
| JPMORGAN CHASE & CO |
3177470 |
2.7% |
| Octagon Capital Advisors LP |
2880880 |
2.5% |
| Siren, L.L.C. |
2816258 |
2.4% |
| Deep Track Capital, LP |
2500000 |
2.2% |
| MORGAN STANLEY |
2118897 |
1.8% |
| DEUTSCHE BANK AG\ |
1842042 |
1.6% |
| GEODE CAPITAL MANAGEMENT, LLC |
1787917 |
1.5% |
| Boxer Capital, LLC |
1726000 |
1.5% |
| Artal Group S.A. |
1467080 |
1.3% |
| Fiera Capital Corp |
1401190 |
1.2% |
| ORBIMED ADVISORS LLC |
1302800 |
1.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1276426 |
1.1% |
| Invesco Ltd. |
1102833 |
1.0% |
| NORGES BANK |
1079605 |
0.9% |
| Polar Capital Holdings Plc |
1079440 |
0.9% |
| BANK OF AMERICA CORP /DE/ |
995069 |
0.9% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
947034 |
0.8% |
| BNP PARIBAS FINANCIAL MARKETS |
850823 |
0.7% |
| EAGLE ASSET MANAGEMENT INC |
802253 |
0.7% |
| AMERIPRISE FINANCIAL INC |
783914 |
0.7% |
| Assenagon Asset Management S.A. |
734708 |
0.6% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
689108 |
0.6% |
| Candriam S.C.A. |
543035 |
0.5% |
| NORTHERN TRUST CORP |
462218 |
0.4% |
| VICTORY CAPITAL MANAGEMENT INC |
461866 |
0.4% |
| Bellevue Group AG |
444404 |
0.4% |
| NEW YORK STATE COMMON RETIREMENT FUND |
431113 |
0.4% |
| Caption Management, LLC |
430000 |
0.4% |
| Logos Global Management LP |
400000 |
0.3% |
| Bank of New York Mellon Corp |
345195 |
0.3% |
| TD ASSET MANAGEMENT INC |
311832 |
0.3% |
| Nuveen Asset Management, LLC |
280001 |
0.2% |
| UBS Group AG |
272397 |
0.2% |
| Pictet Asset Management Holding SA |
253048 |
0.2% |
| AQR CAPITAL MANAGEMENT LLC |
246880 |
0.2% |
| PRUDENTIAL FINANCIAL INC |
245260 |
0.2% |
| Rafferty Asset Management, LLC |
241982 |
0.2% |
| FIDUCIARY TRUST CO |
240286 |
0.2% |
| abrdn plc |
236724 |
0.2% |
| FRANKLIN RESOURCES INC |
225932 |
0.2% |
| BARCLAYS PLC |
216878 |
0.2% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
212887 |
0.2% |
| EVENTIDE ASSET MANAGEMENT, LLC |
209794 |
0.2% |
| MILLENNIUM MANAGEMENT LLC |
205911 |
0.2% |
| CAPITAL FUND MANAGEMENT S.A. |
201487 |
0.2% |
| JANE STREET GROUP, LLC |
200889 |
0.2% |
| BALYASNY ASSET MANAGEMENT L.P. |
199954 |
0.2% |
| Woodline Partners LP |
187000 |
0.2% |
| 683 Capital Management, LLC |
186000 |
0.2% |
| MACQUARIE GROUP LTD |
184931 |
0.2% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
173574 |
0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
168403 |
0.1% |
| WELLS FARGO & COMPANY/MN |
160228 |
0.1% |
| Swiss National Bank |
154700 |
0.1% |
| CITADEL ADVISORS LLC |
153891 |
0.1% |
| Trexquant Investment LP |
149160 |
0.1% |
| GOLDMAN SACHS GROUP INC |
146926 |
0.1% |
| Rock Springs Capital Management LP |
140700 |
0.1% |
| Ghost Tree Capital, LLC |
135000 |
0.1% |
| ENVESTNET ASSET MANAGEMENT INC |
134536 |
0.1% |
| BANK OF MONTREAL /CAN/ |
132318 |
0.1% |
| FIRST TRUST ADVISORS LP |
123725 |
0.1% |
| ALGERT GLOBAL LLC |
123628 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
123616 |
0.1% |
| RHUMBLINE ADVISERS |
123565 |
0.1% |
| Granahan Investment Management, LLC |
122383 |
0.1% |
| Exome Asset Management LLC |
119467 |
0.1% |
| Hudson Bay Capital Management LP |
115000 |
0.1% |
| PEREGRINE CAPITAL MANAGEMENT LLC |
114279 |
0.1% |
| SG Americas Securities, LLC |
107561 |
0.1% |
| Legal & General Group Plc |
101358 |
0.1% |
| PDT Partners, LLC |
92856 |
0.1% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
91818 |
0.1% |
| PFM Health Sciences, LP |
82952 |
0.1% |
| Steward Partners Investment Advisory, LLC |
81800 |
0.1% |
| Bleakley Financial Group, LLC |
78746 |
0.1% |
| Simplicity Wealth,LLC |
78746 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
78702 |
0.1% |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
77561 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
77349 |
0.1% |
| Man Group plc |
77229 |
0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
73135 |
0.1% |
| ExodusPoint Capital Management, LP |
73133 |
0.1% |
| Allspring Global Investments Holdings, LLC |
72468 |
0.1% |
| SIMPLEX TRADING, LLC |
70072 |
0.1% |
| HAP Trading, LLC |
64997 |
0.1% |
| PNC FINANCIAL SERVICES GROUP, INC. |
59088 |
0.1% |
| TWINBEECH CAPITAL LP |
58072 |
0.1% |
| Rhenman & Partners Asset Management AB |
55395 |
47.7‰ |
| DekaBank Deutsche Girozentrale |
55000 |
47.4‰ |
