| FMR LLC |
10483883 |
8.1% |
| VANGUARD GROUP INC |
6509753 |
5.0% |
| BlackRock, Inc. |
5143071 |
4.0% |
| BlackRock Finance, Inc. |
4916127 |
3.8% |
| ARMISTICE CAPITAL, LLC |
3396909 |
2.6% |
| Deep Track Capital, LP |
2883736 |
2.2% |
| STATE STREET CORP |
2718956 |
2.1% |
| VIKING GLOBAL INVESTORS LP |
2320902 |
1.8% |
| PERCEPTIVE ADVISORS LLC |
1923786 |
1.5% |
| Woodline Partners LP |
1823415 |
1.4% |
| T. Rowe Price Investment Management, Inc. |
1625220 |
1.2% |
| GEODE CAPITAL MANAGEMENT, LLC |
1414002 |
1.1% |
| Paradigm Biocapital Advisors LP |
1362827 |
1.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1361649 |
1.0% |
| Rock Springs Capital Management LP |
1185654 |
0.9% |
| Pictet Asset Management Holding SA |
1174816 |
0.9% |
| Nuveen Asset Management, LLC |
1144849 |
0.9% |
| STEMPOINT CAPITAL LP |
1118508 |
0.9% |
| FRANKLIN RESOURCES INC |
1101868 |
0.8% |
| Capital Research Global Investors |
976237 |
0.7% |
| Avidity Partners Management LP |
908000 |
0.7% |
| Boxer Capital, LLC |
825000 |
0.6% |
| MORGAN STANLEY |
817038 |
0.6% |
| ADAR1 Capital Management, LLC |
787478 |
0.6% |
| COMMODORE CAPITAL LP |
750990 |
0.6% |
| Redmile Group, LLC |
720177 |
0.6% |
| First Turn Management, LLC |
695428 |
0.5% |
| Two Seas Capital LP |
692406 |
0.5% |
| FRED ALGER MANAGEMENT, LLC |
607724 |
0.5% |
| NORGES BANK |
601861 |
0.5% |
| Logos Global Management LP |
575000 |
0.4% |
| Invesco Ltd. |
570898 |
0.4% |
| PRINCIPAL FINANCIAL GROUP INC |
559688 |
0.4% |
| DIMENSIONAL FUND ADVISORS LP |
494689 |
0.4% |
| PFM Health Sciences, LP |
472540 |
0.4% |
| BAKER BROS. ADVISORS LP |
464718 |
0.4% |
| NORTHERN TRUST CORP |
463721 |
0.4% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
461171 |
0.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
420000 |
0.3% |
| GOLDMAN SACHS GROUP INC |
411918 |
0.3% |
| abrdn plc |
400722 |
0.3% |
| RENAISSANCE TECHNOLOGIES LLC |
388100 |
0.3% |
| Affinity Asset Advisors, LLC |
346088 |
0.3% |
| CITADEL ADVISORS LLC |
343512 |
0.3% |
| Prosight Management, LP |
325000 |
0.2% |
| VICTORY CAPITAL MANAGEMENT INC |
312370 |
0.2% |
| Assenagon Asset Management S.A. |
311525 |
0.2% |
| EMERALD ADVISERS, LLC |
288564 |
0.2% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
279252 |
0.2% |
| Skandinaviska Enskilda Banken AB (publ) |
277022 |
0.2% |
| Ikarian Capital, LLC |
276925 |
0.2% |
| MILLENNIUM MANAGEMENT LLC |
275352 |
0.2% |
| Ghost Tree Capital, LLC |
260000 |
0.2% |
| JPMORGAN CHASE & CO |
256843 |
0.2% |
| Soleus Capital Management, L.P. |
251900 |
0.2% |
| Bank of New York Mellon Corp |
250339 |
0.2% |
| BANK OF AMERICA CORP /DE/ |
243334 |
0.2% |
| Connor, Clark & Lunn Investment Management Ltd. |
238588 |
0.2% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
201087 |
0.2% |
| CANADA PENSION PLAN INVESTMENT BOARD |
199800 |
0.2% |
| PLATINUM INVESTMENT MANAGEMENT LTD |
192242 |
0.1% |
| WCM INVESTMENT MANAGEMENT, LLC |
175542 |
0.1% |
| Russell Investments Group, Ltd. |
175195 |
0.1% |
| DEUTSCHE BANK AG\ |
142974 |
0.1% |
| Rafferty Asset Management, LLC |
140698 |
0.1% |
| JANE STREET GROUP, LLC |
140317 |
0.1% |
| Rhenman & Partners Asset Management AB |
130500 |
0.1% |
| ExodusPoint Capital Management, LP |
126660 |
0.1% |
| MACQUARIE GROUP LTD |
122100 |
0.1% |
| ALGERT GLOBAL LLC |
120938 |
0.1% |
| UBS Group AG |
119355 |
0.1% |
| ALPS ADVISORS INC |
113931 |
0.1% |
| Swiss National Bank |
99600 |
0.1% |
| AXA S.A. |
98810 |
0.1% |
| BARCLAYS PLC |
98440 |
0.1% |
| Eversept Partners, LP |
92909 |
0.1% |
| AQR CAPITAL MANAGEMENT LLC |
86283 |
0.1% |
| BNP PARIBAS FINANCIAL MARKETS |
85201 |
0.1% |
| GROUP ONE TRADING LLC |
84708 |
0.1% |
| RHUMBLINE ADVISERS |
83532 |
0.1% |
| Blue Owl Capital Holdings LP |
80000 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
71745 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
71450 |
0.1% |
| ArrowMark Colorado Holdings LLC |
70000 |
0.1% |
| BANQUE PICTET & CIE SA |
68152 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
65046 |
0.1% |
| BOOTHBAY FUND MANAGEMENT, LLC |
64796 |
49.8‰ |
| Allspring Global Investments Holdings, LLC |
60947 |
46.8‰ |
| Rubric Capital Management LP |
58624 |
45.0‰ |
| EFG Asset Management (North America) Corp. |
58070 |
44.6‰ |
| Legal & General Group Plc |
57682 |
44.3‰ |
| SIMPLEX TRADING, LLC |
56961 |
43.7‰ |
| Tejara Capital Ltd |
55210 |
42.4‰ |
| BAMCO INC /NY/ |
55000 |
42.2‰ |
| Erste Asset Management GmbH |
52500 |
40.3‰ |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
50235 |
38.6‰ |
| AWM Investment Company, Inc. |
50000 |
38.4‰ |
| DAFNA Capital Management LLC |
47916 |
36.8‰ |
| D. E. Shaw & Co., Inc. |
41479 |
31.9‰ |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
37626 |
28.9‰ |
