| BlackRock, Inc. |
11191986 |
12.7% |
| BlackRock Finance, Inc. |
10324404 |
11.7% |
| VANGUARD GROUP INC |
9035624 |
10.2% |
| Capital International Investors |
4320827 |
4.9% |
| STATE STREET CORP |
4141793 |
4.7% |
| JANUS HENDERSON GROUP PLC |
3815368 |
4.3% |
| Avoro Capital Advisors LLC |
3000000 |
3.4% |
| MORGAN STANLEY |
2623361 |
3.0% |
| FARALLON CAPITAL MANAGEMENT LLC |
2295000 |
2.6% |
| Bank of New York Mellon Corp |
2130651 |
2.4% |
| WELLINGTON MANAGEMENT GROUP LLP |
2061526 |
2.3% |
| T. Rowe Price Investment Management, Inc. |
1958635 |
2.2% |
| FMR LLC |
1860545 |
2.1% |
| JPMORGAN CHASE & CO |
1843769 |
2.1% |
| GEODE CAPITAL MANAGEMENT, LLC |
1652048 |
1.9% |
| DEUTSCHE BANK AG\ |
1573577 |
1.8% |
| EcoR1 Capital, LLC |
1407322 |
1.6% |
| Casdin Capital, LLC |
1073500 |
1.2% |
| Pictet Asset Management Holding SA |
957218 |
1.1% |
| Paradigm Biocapital Advisors LP |
947574 |
1.1% |
| NORGES BANK |
924428 |
1.0% |
| JANE STREET GROUP, LLC |
869129 |
1.0% |
| CITADEL ADVISORS LLC |
775821 |
0.9% |
| BANK OF AMERICA CORP /DE/ |
721401 |
0.8% |
| Erste Asset Management GmbH |
708248 |
0.8% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
690408 |
0.8% |
| NORTHERN TRUST CORP |
668078 |
0.8% |
| Boxer Capital, LLC |
650000 |
0.7% |
| ORBIMED ADVISORS LLC |
646000 |
0.7% |
| THRIVENT FINANCIAL FOR LUTHERANS |
644675 |
0.7% |
| TWO SIGMA ADVISERS, LP |
606834 |
0.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
604757 |
0.7% |
| MILLENNIUM MANAGEMENT LLC |
572275 |
0.6% |
| ALKEON CAPITAL MANAGEMENT LLC |
558845 |
0.6% |
| TWO SIGMA INVESTMENTS, LP |
541794 |
0.6% |
| BALYASNY ASSET MANAGEMENT L.P. |
532918 |
0.6% |
| FEDERATED HERMES, INC. |
508329 |
0.6% |
| Nuveen Asset Management, LLC |
483235 |
0.5% |
| GOLDMAN SACHS GROUP INC |
439577 |
0.5% |
| EAGLE ASSET MANAGEMENT INC |
406046 |
0.5% |
| BARCLAYS PLC |
400898 |
0.5% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
400000 |
0.5% |
| Man Group plc |
386424 |
0.4% |
| Fiera Capital Corp |
382645 |
0.4% |
| Invesco Ltd. |
380377 |
0.4% |
| PRINCIPAL FINANCIAL GROUP INC |
363011 |
0.4% |
| Assenagon Asset Management S.A. |
359696 |
0.4% |
| RENAISSANCE TECHNOLOGIES LLC |
352000 |
0.4% |
| UBS Group AG |
350764 |
0.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
340030 |
0.4% |
| Amundi |
332956 |
0.4% |
| abrdn plc |
329845 |
0.4% |
| MIZUHO MARKETS AMERICAS LLC |
326300 |
0.4% |
| VOYA INVESTMENT MANAGEMENT LLC |
322835 |
0.4% |
| FRED ALGER MANAGEMENT, LLC |
318252 |
0.4% |
| AMERIPRISE FINANCIAL INC |
308413 |
0.3% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
299301 |
0.3% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
288617 |
0.3% |
| Rock Springs Capital Management LP |
284000 |
0.3% |
| RHUMBLINE ADVISERS |
270941 |
0.3% |
| DIMENSIONAL FUND ADVISORS LP |
255396 |
0.3% |
| BANK OF NOVA SCOTIA |
252825 |
0.3% |
| Bellevue Group AG |
252321 |
0.3% |
| FRANKLIN RESOURCES INC |
243642 |
0.3% |
| Clearbridge Investments, LLC |
237354 |
0.3% |
| CANADA PENSION PLAN INVESTMENT BOARD |
230300 |
0.3% |
| EVENTIDE ASSET MANAGEMENT, LLC |
228529 |
0.3% |
| Caption Management, LLC |
227000 |
0.3% |
| ALLIANCEBERNSTEIN L.P. |
214371 |
0.2% |
| Ikarian Capital, LLC |
203612 |
0.2% |
| Palo Alto Investors LP |
201683 |
0.2% |
| Sofinnova Investments, Inc. |
195852 |
0.2% |
| First Turn Management, LLC |
181669 |
0.2% |
| BANK OF MONTREAL /CAN/ |
177890 |
0.2% |
| BLAIR WILLIAM & CO/IL |
174282 |
0.2% |
| Swiss National Bank |
166083 |
0.2% |
| TD ASSET MANAGEMENT INC |
159082 |
0.2% |
| NEW YORK STATE COMMON RETIREMENT FUND |
158462 |
0.2% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
151851 |
0.2% |
| Logos Global Management LP |
150000 |
0.2% |
| Camber Capital Management LP |
150000 |
0.2% |
| Cubist Systematic Strategies, LLC |
148114 |
0.2% |
| Legal & General Group Plc |
147614 |
0.2% |
| Rafferty Asset Management, LLC |
146584 |
0.2% |
| C WorldWide Group Holding A/S |
140329 |
0.2% |
| Swedbank AB |
137400 |
0.2% |
| Finepoint Capital LP |
132835 |
0.2% |
| Candriam S.C.A. |
129000 |
0.1% |
| Cormorant Asset Management, LP |
125000 |
0.1% |
| Russell Investments Group, Ltd. |
121754 |
0.1% |
| D. E. Shaw & Co., Inc. |
117840 |
0.1% |
| ExodusPoint Capital Management, LP |
117215 |
0.1% |
| Retirement Systems of Alabama |
116667 |
0.1% |
| WELLS FARGO & COMPANY/MN |
107570 |
0.1% |
| FIRST TRUST ADVISORS LP |
101916 |
0.1% |
| BRAUN STACEY ASSOCIATES INC |
98185 |
0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
89525 |
0.1% |
| Neuberger Berman Group LLC |
88451 |
0.1% |
| PFM Health Sciences, LP |
88216 |
0.1% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
85860 |
0.1% |
