| FMR LLC |
21894806 |
15.3% |
| VANGUARD GROUP INC |
13845712 |
9.7% |
| T. Rowe Price Investment Management, Inc. |
12639684 |
8.9% |
| BlackRock, Inc. |
11665548 |
8.2% |
| BlackRock Finance, Inc. |
10321030 |
7.2% |
| Bellevue Group AG |
8260434 |
5.8% |
| WELLINGTON MANAGEMENT GROUP LLP |
6568808 |
4.6% |
| STATE STREET CORP |
4190505 |
2.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
3934311 |
2.8% |
| Tweedy, Browne Co LLC |
3454676 |
2.4% |
| BVF INC/IL |
3186376 |
2.2% |
| GEODE CAPITAL MANAGEMENT, LLC |
2484544 |
1.7% |
| Pictet Asset Management Holding SA |
2409954 |
1.7% |
| ORBIMED ADVISORS LLC |
2372333 |
1.7% |
| Capital World Investors |
2252089 |
1.6% |
| Clearbridge Investments, LLC |
2160270 |
1.5% |
| Deep Track Capital, LP |
2000000 |
1.4% |
| MACQUARIE GROUP LTD |
1873668 |
1.3% |
| Artisan Partners Limited Partnership |
1671036 |
1.2% |
| ARK Investment Management LLC |
1361025 |
1.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
1328106 |
0.9% |
| TWO SIGMA ADVISERS, LP |
1287111 |
0.9% |
| BALYASNY ASSET MANAGEMENT L.P. |
1077321 |
0.8% |
| TWO SIGMA INVESTMENTS, LP |
1028142 |
0.7% |
| NORGES BANK |
1019341 |
0.7% |
| MORGAN STANLEY |
1012805 |
0.7% |
| Invesco Ltd. |
968917 |
0.7% |
| TD ASSET MANAGEMENT INC |
952762 |
0.7% |
| Candriam S.C.A. |
948266 |
0.7% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
800000 |
0.6% |
| BNP Paribas Asset Management Holding S.A. |
780753 |
0.5% |
| Schonfeld Strategic Advisors LLC |
723618 |
0.5% |
| NORTHERN TRUST CORP |
717975 |
0.5% |
| Man Group plc |
633409 |
0.4% |
| CITADEL ADVISORS LLC |
627033 |
0.4% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
619641 |
0.4% |
| BARCLAYS PLC |
615674 |
0.4% |
| Bank of New York Mellon Corp |
597479 |
0.4% |
| JPMORGAN CHASE & CO |
594091 |
0.4% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
572870 |
0.4% |
| BANK OF AMERICA CORP /DE/ |
514543 |
0.4% |
| NOMURA HOLDINGS INC |
501188 |
0.4% |
| AXA S.A. |
464963 |
0.3% |
| Eversept Partners, LP |
456881 |
0.3% |
| PINNACLE ASSOCIATES LTD |
453379 |
0.3% |
| Nuveen Asset Management, LLC |
410404 |
0.3% |
| WELLS FARGO & COMPANY/MN |
366561 |
0.3% |
| Hudson Bay Capital Management LP |
366000 |
0.3% |
| GREAT POINT PARTNERS LLC |
330000 |
0.2% |
| GOLDMAN SACHS GROUP INC |
328305 |
0.2% |
| Logos Global Management LP |
300000 |
0.2% |
| C WorldWide Group Holding A/S |
300000 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
274850 |
0.2% |
| BAILLIE GIFFORD & CO |
260254 |
0.2% |
| Swiss National Bank |
258000 |
0.2% |
| BNP PARIBAS FINANCIAL MARKETS |
254521 |
0.2% |
| KENNEDY CAPITAL MANAGEMENT LLC |
254343 |
0.2% |
| Integral Health Asset Management, LLC |
250000 |
0.2% |
| Siren, L.L.C. |
250000 |
0.2% |
| RENAISSANCE TECHNOLOGIES LLC |
249514 |
0.2% |
| Privium Fund Management B.V. |
247267 |
0.2% |
| abrdn plc |
246917 |
0.2% |
| TOCQUEVILLE ASSET MANAGEMENT L.P. |
225070 |
0.2% |
| BANK OF MONTREAL /CAN/ |
220518 |
0.2% |
| STIFEL FINANCIAL CORP |
216140 |
0.2% |
| Orion Investment Co |
216000 |
0.2% |
| NEW YORK STATE COMMON RETIREMENT FUND |
215716 |
0.2% |
| ExodusPoint Capital Management, LP |
209194 |
0.1% |
| Zimmer Partners, LP |
200000 |
0.1% |
| Nikko Asset Management Americas, Inc. |
199231 |
0.1% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
196484 |
0.1% |
| Sicart Associates LLC |
191523 |
0.1% |
| D. E. Shaw & Co., Inc. |
190781 |
0.1% |
| ALTRINSIC GLOBAL ADVISORS LLC |
187831 |
0.1% |
| JANE STREET GROUP, LLC |
179246 |
0.1% |
| RHUMBLINE ADVISERS |
178089 |
0.1% |
| MARSHALL WACE, LLP |
173199 |
0.1% |
| SECTOR GAMMA AS |
170000 |
0.1% |
| Rafferty Asset Management, LLC |
168856 |
0.1% |
| Legal & General Group Plc |
161643 |
0.1% |
| Caption Management, LLC |
160000 |
0.1% |
| HRT FINANCIAL LP |
159685 |
0.1% |
| Sumitomo Mitsui Trust Group, Inc. |
156657 |
0.1% |
| BLB&B Advisors, LLC |
153750 |
0.1% |
| UBS Group AG |
152672 |
0.1% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
151055 |
0.1% |
| Sonora Investment Management Group, LLC |
150814 |
0.1% |
| TANG CAPITAL MANAGEMENT LLC |
150000 |
0.1% |
| SPHERA FUNDS MANAGEMENT LTD. |
140238 |
0.1% |
| Point72 Asset Management, L.P. |
137210 |
0.1% |
| Russell Investments Group, Ltd. |
132736 |
0.1% |
| SEI INVESTMENTS CO |
132311 |
0.1% |
| PEREGRINE CAPITAL MANAGEMENT LLC |
132024 |
0.1% |
| Rhenman & Partners Asset Management AB |
130000 |
0.1% |
| Amundi |
129475 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
129216 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
128215 |
0.1% |
| Swedbank AB |
124237 |
0.1% |
| Verition Fund Management LLC |
120814 |
0.1% |
| Granite Investment Partners, LLC |
114090 |
0.1% |
