| Artal Group S.A. |
11259438 |
14.1% |
| FMR LLC |
9887233 |
12.4% |
| Siren, L.L.C. |
9250005 |
11.6% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
8188127 |
10.2% |
| BlackRock, Inc. |
7172370 |
9.0% |
| Samsara BioCapital, LLC |
6788609 |
8.5% |
| BlackRock Finance, Inc. |
5664419 |
7.1% |
| Redmile Group, LLC |
5453083 |
6.8% |
| VANGUARD GROUP INC |
3836560 |
4.8% |
| EVENTIDE ASSET MANAGEMENT, LLC |
3074475 |
3.8% |
| Polar Capital Holdings Plc |
2940672 |
3.7% |
| STATE STREET CORP |
2808924 |
3.5% |
| Bellevue Group AG |
2165203 |
2.7% |
| GEODE CAPITAL MANAGEMENT, LLC |
1422536 |
1.8% |
| GOLDMAN SACHS GROUP INC |
1339081 |
1.7% |
| ORBIMED ADVISORS LLC |
1074382 |
1.3% |
| MPM BioImpact LLC |
1028330 |
1.3% |
| MILLENNIUM MANAGEMENT LLC |
925584 |
1.2% |
| Hood River Capital Management LLC |
832792 |
1.0% |
| TWO SIGMA INVESTMENTS, LP |
800672 |
1.0% |
| Clearbridge Investments, LLC |
747105 |
0.9% |
| Candriam S.C.A. |
744443 |
0.9% |
| Woodline Partners LP |
708187 |
0.9% |
| TWO SIGMA ADVISERS, LP |
590800 |
0.7% |
| abrdn plc |
583774 |
0.7% |
| NORTHERN TRUST CORP |
505224 |
0.6% |
| MARSHALL WACE, LLP |
487285 |
0.6% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
460654 |
0.6% |
| Cubist Systematic Strategies, LLC |
439557 |
0.5% |
| UBS Group AG |
425312 |
0.5% |
| Integral Health Asset Management, LLC |
400000 |
0.5% |
| AMERIPRISE FINANCIAL INC |
381025 |
0.5% |
| Deep Track Capital, LP |
372559 |
0.5% |
| AXA S.A. |
372250 |
0.5% |
| BALYASNY ASSET MANAGEMENT L.P. |
366078 |
0.5% |
| TD ASSET MANAGEMENT INC |
309646 |
0.4% |
| KENNEDY CAPITAL MANAGEMENT LLC |
279951 |
0.3% |
| Trexquant Investment LP |
272795 |
0.3% |
| CITIGROUP INC |
269281 |
0.3% |
| D. E. Shaw & Co., Inc. |
254039 |
0.3% |
| BANK OF AMERICA CORP /DE/ |
253527 |
0.3% |
| DIMENSIONAL FUND ADVISORS LP |
248736 |
0.3% |
| MORGAN STANLEY |
247567 |
0.3% |
| Bank of New York Mellon Corp |
230450 |
0.3% |
| Qube Research & Technologies Ltd |
225145 |
0.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
222800 |
0.3% |
| Laurion Capital Management LP |
214972 |
0.3% |
| Schonfeld Strategic Advisors LLC |
207491 |
0.3% |
| Nuveen Asset Management, LLC |
195119 |
0.2% |
| Ikarian Capital, LLC |
183701 |
0.2% |
| WELLINGTON MANAGEMENT GROUP LLP |
171976 |
0.2% |
| J. Goldman & Co LP |
171094 |
0.2% |
| STEMPOINT CAPITAL LP |
166307 |
0.2% |
| JANE STREET GROUP, LLC |
155788 |
0.2% |
| JENNISON ASSOCIATES LLC |
140776 |
0.2% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
135231 |
0.2% |
| Rafferty Asset Management, LLC |
132991 |
0.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
125000 |
0.2% |
| CANADA PENSION PLAN INVESTMENT BOARD |
120000 |
0.1% |
| CITADEL ADVISORS LLC |
112996 |
0.1% |
| Fisher Asset Management, LLC |
105833 |
0.1% |
| RHUMBLINE ADVISERS |
101278 |
0.1% |
| RENAISSANCE TECHNOLOGIES LLC |
92364 |
0.1% |
| Swiss National Bank |
84200 |
0.1% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
84037 |
0.1% |
| BARCLAYS PLC |
81331 |
0.1% |
| Atom Investors LP |
77515 |
0.1% |
| Exome Asset Management LLC |
77439 |
0.1% |
| FIRST TRUST ADVISORS LP |
76347 |
0.1% |
| Walleye Capital LLC |
74292 |
0.1% |
| RAYMOND JAMES & ASSOCIATES |
68478 |
0.1% |
| ClariVest Asset Management LLC |
59640 |
0.1% |
| GSA CAPITAL PARTNERS LLP |
58870 |
0.1% |
| EXCHANGE TRADED CONCEPTS, LLC |
58222 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
56870 |
0.1% |
| OCCUDO QUANTITATIVE STRATEGIES LP |
56850 |
0.1% |
| E. Ohman J:or Asset Management AB |
53500 |
0.1% |
| Legal & General Group Plc |
51141 |
0.1% |
| BOOTHBAY FUND MANAGEMENT, LLC |
48846 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
47215 |
0.1% |
| RICE HALL JAMES & ASSOCIATES, LLC |
46000 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
45492 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
43808 |
0.1% |
| Graham Capital Management, L.P. |
41410 |
0.1% |
| Cinctive Capital Management LP |
40033 |
0.1% |
| MetLife Investment Management, LLC |
39966 |
0.1% |
| AQR CAPITAL MANAGEMENT LLC |
39754 |
49.7‰ |
| TUDOR INVESTMENT CORP ET AL |
39713 |
49.7‰ |
| JPMORGAN CHASE & CO |
38347 |
47.9‰ |
| DekaBank Deutsche Girozentrale |
38000 |
47.5‰ |
| Engineers Gate Manager LP |
37924 |
47.4‰ |
| LPL Financial LLC |
37667 |
47.1‰ |
| Jasper Ridge Partners, L.P. |
31568 |
39.5‰ |
| DEUTSCHE BANK AG\ |
29881 |
37.4‰ |
| Dynamic Technology Lab Private Ltd |
28444 |
35.6‰ |
| STATE OF WISCONSIN INVESTMENT BOARD |
28144 |
35.2‰ |
| Values First Advisors, Inc. |
25979 |
32.5‰ |
| PROFUND ADVISORS LLC |
24980 |
31.2‰ |
| WELLS FARGO & COMPANY/MN |
24526 |
30.7‰ |
| Virtu Financial LLC |
23960 |
30.0‰ |
