| BlackRock, Inc. |
16032944 |
11.7% |
| VANGUARD GROUP INC |
16013010 |
11.7% |
| BlackRock Finance, Inc. |
14264495 |
10.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
12163368 |
8.9% |
| FMR LLC |
7305130 |
5.3% |
| Capital International Investors |
5869888 |
4.3% |
| STATE STREET CORP |
4662439 |
3.4% |
| GEODE CAPITAL MANAGEMENT, LLC |
3640720 |
2.6% |
| RTW INVESTMENTS, LP |
3640108 |
2.6% |
| BAKER BROS. ADVISORS LP |
3576038 |
2.6% |
| Darwin Global Management, Ltd. |
3541095 |
2.6% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
3469728 |
2.5% |
| JPMORGAN CHASE & CO |
2926185 |
2.1% |
| MACQUARIE GROUP LTD |
2746628 |
2.0% |
| FRANKLIN RESOURCES INC |
2718290 |
2.0% |
| AMERIPRISE FINANCIAL INC |
2530994 |
1.8% |
| ALLIANCEBERNSTEIN L.P. |
2492275 |
1.8% |
| Artisan Partners Limited Partnership |
2489431 |
1.8% |
| T. Rowe Price Investment Management, Inc. |
2435962 |
1.8% |
| Palo Alto Investors LP |
2138963 |
1.6% |
| JANUS HENDERSON GROUP PLC |
2091778 |
1.5% |
| Deep Track Capital, LP |
2000000 |
1.5% |
| Bank of New York Mellon Corp |
1807370 |
1.3% |
| NORGES BANK |
1757425 |
1.3% |
| PRINCIPAL FINANCIAL GROUP INC |
1657760 |
1.2% |
| Clearbridge Investments, LLC |
1644948 |
1.2% |
| Integral Health Asset Management, LLC |
1550000 |
1.1% |
| FIL Ltd |
1518114 |
1.1% |
| Pictet Asset Management Holding SA |
1491135 |
1.1% |
| NORTHERN TRUST CORP |
1392107 |
1.0% |
| Nuveen Asset Management, LLC |
1329947 |
1.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
1325000 |
1.0% |
| Hood River Capital Management LLC |
1315392 |
1.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
1306596 |
1.0% |
| MARSHALL WACE, LLP |
1249351 |
0.9% |
| LOOMIS SAYLES & CO L P |
1226726 |
0.9% |
| MILLENNIUM MANAGEMENT LLC |
1198510 |
0.9% |
| GOLDMAN SACHS GROUP INC |
1189901 |
0.9% |
| Eversept Partners, LP |
1155588 |
0.8% |
| BANK OF AMERICA CORP /DE/ |
1119208 |
0.8% |
| VIKING GLOBAL INVESTORS LP |
1035970 |
0.8% |
| Bellevue Group AG |
1021700 |
0.7% |
| WELLINGTON MANAGEMENT GROUP LLP |
938434 |
0.7% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
922002 |
0.7% |
| Point72 Asset Management, L.P. |
858300 |
0.6% |
| JANE STREET GROUP, LLC |
840000 |
0.6% |
| MORGAN STANLEY |
822804 |
0.6% |
| Rock Springs Capital Management LP |
808356 |
0.6% |
| Novo Holdings A/S |
800000 |
0.6% |
| CITADEL ADVISORS LLC |
799746 |
0.6% |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
774404 |
0.6% |
| GW&K Investment Management, LLC |
761732 |
0.6% |
| Invesco Ltd. |
756241 |
0.6% |
| AMERICAN CENTURY COMPANIES INC |
755271 |
0.5% |
| JENNISON ASSOCIATES LLC |
744280 |
0.5% |
| Long Focus Capital Management, LLC |
740900 |
0.5% |
| VOYA INVESTMENT MANAGEMENT LLC |
732422 |
0.5% |
| EVENTIDE ASSET MANAGEMENT, LLC |
675185 |
0.5% |
| Cormorant Asset Management, LP |
675000 |
0.5% |
| BNP Paribas Asset Management Holding S.A. |
654348 |
0.5% |
| Octagon Capital Advisors LP |
650216 |
0.5% |
| EMERALD ADVISERS, LLC |
640267 |
0.5% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
625000 |
0.5% |
| MPM BioImpact LLC |
615391 |
0.4% |
| Fiera Capital Corp |
605527 |
0.4% |
| LORD, ABBETT & CO. LLC |
582577 |
0.4% |
| FARALLON CAPITAL MANAGEMENT LLC |
568000 |
0.4% |
| Candriam S.C.A. |
555934 |
0.4% |
| First Light Asset Management, LLC |
551303 |
0.4% |
| TD ASSET MANAGEMENT INC |
525682 |
0.4% |
| Eagle Health Investments LP |
513700 |
0.4% |
| FRED ALGER MANAGEMENT, LLC |
498572 |
0.4% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
493849 |
0.4% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
486847 |
0.4% |
| SOROS FUND MANAGEMENT LLC |
470700 |
0.3% |
| Hudson Bay Capital Management LP |
467500 |
0.3% |
| Avidity Partners Management LP |
430000 |
0.3% |
| Alyeska Investment Group, L.P. |
428804 |
0.3% |
| Iron Triangle Partners LP |
413196 |
0.3% |
| Assenagon Asset Management S.A. |
391054 |
0.3% |
| SAMLYN CAPITAL, LLC |
359254 |
0.3% |
| PANAGORA ASSET MANAGEMENT INC |
356135 |
0.3% |
| C WorldWide Group Holding A/S |
343110 |
0.2% |
| Allspring Global Investments Holdings, LLC |
328073 |
0.2% |
| First Turn Management, LLC |
323360 |
0.2% |
| NEW YORK STATE COMMON RETIREMENT FUND |
322299 |
0.2% |
| Tri Locum Partners LP |
316501 |
0.2% |
| EAGLE ASSET MANAGEMENT INC |
314690 |
0.2% |
| TWO SIGMA ADVISERS, LP |
295400 |
0.2% |
| D. E. Shaw & Co., Inc. |
288551 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
283011 |
0.2% |
| SEI INVESTMENTS CO |
277712 |
0.2% |
| Swiss National Bank |
277500 |
0.2% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
271535 |
0.2% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
270960 |
0.2% |
| Granahan Investment Management, LLC |
259275 |
0.2% |
| DEUTSCHE BANK AG\ |
255989 |
0.2% |
| Polar Capital Holdings Plc |
255000 |
0.2% |
| GREAT POINT PARTNERS LLC |
250000 |
0.2% |
| PFM Health Sciences, LP |
241315 |
0.2% |
