| T. Rowe Price Investment Management, Inc. |
10659730 |
26.6% |
| Bellevue Group AG |
8517839 |
21.2% |
| NEA Management Company, LLC |
4448757 |
11.1% |
| BlackRock, Inc. |
3519145 |
8.8% |
| BlackRock Finance, Inc. |
3217128 |
8.0% |
| VANGUARD GROUP INC |
2131624 |
5.3% |
| TANG CAPITAL MANAGEMENT LLC |
1603200 |
4.0% |
| Artal Group S.A. |
1046517 |
2.6% |
| Siren, L.L.C. |
1046517 |
2.6% |
| MILLENNIUM MANAGEMENT LLC |
1004878 |
2.5% |
| GEODE CAPITAL MANAGEMENT, LLC |
842432 |
2.1% |
| Ally Bridge Group (NY) LLC |
835000 |
2.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
813066 |
2.0% |
| Invesco Ltd. |
712382 |
1.8% |
| KENNEDY CAPITAL MANAGEMENT LLC |
703283 |
1.8% |
| STATE STREET CORP |
690432 |
1.7% |
| Affinity Asset Advisors, LLC |
650000 |
1.6% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
605901 |
1.5% |
| ExodusPoint Capital Management, LP |
588628 |
1.5% |
| Boxer Capital, LLC |
506000 |
1.3% |
| Connor, Clark & Lunn Investment Management Ltd. |
286846 |
0.7% |
| TD ASSET MANAGEMENT INC |
266312 |
0.7% |
| RENAISSANCE TECHNOLOGIES LLC |
263900 |
0.7% |
| MORGAN STANLEY |
216328 |
0.5% |
| DIMENSIONAL FUND ADVISORS LP |
200044 |
0.5% |
| TWO SIGMA INVESTMENTS, LP |
183227 |
0.5% |
| WELLINGTON MANAGEMENT GROUP LLP |
181675 |
0.5% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
173000 |
0.4% |
| STIFEL FINANCIAL CORP |
147500 |
0.4% |
| Verition Fund Management LLC |
125250 |
0.3% |
| NORTHERN TRUST CORP |
124154 |
0.3% |
| Qube Research & Technologies Ltd |
123034 |
0.3% |
| Nuveen Asset Management, LLC |
122003 |
0.3% |
| Foundations Investment Advisors, LLC |
113550 |
0.3% |
| Bank of New York Mellon Corp |
108959 |
0.3% |
| CANTOR FITZGERALD, L. P. |
105039 |
0.3% |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
104560 |
0.3% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
102203 |
0.3% |
| Newtyn Management, LLC |
95000 |
0.2% |
| MARSHALL WACE, LLP |
94537 |
0.2% |
| GOLDMAN SACHS GROUP INC |
63120 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
60189 |
0.1% |
| CORNERCAP INVESTMENT COUNSEL INC |
48110 |
0.1% |
| RHUMBLINE ADVISERS |
46850 |
0.1% |
| Pale Fire Capital SE |
39000 |
0.1% |
| BANK OF MONTREAL /CAN/ |
28593 |
0.1% |
| ALGERT GLOBAL LLC |
28501 |
0.1% |
| UBS Group AG |
26534 |
0.1% |
| BARCLAYS PLC |
25886 |
0.1% |
| SG Americas Securities, LLC |
23146 |
0.1% |
| Point72 (DIFC) Ltd |
23021 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
22766 |
0.1% |
| DEUTSCHE BANK AG\ |
22388 |
0.1% |
| NEW YORK STATE COMMON RETIREMENT FUND |
21300 |
0.1% |
| SIMPLEX TRADING, LLC |
21034 |
0.1% |
| Marathon Trading Investment Management LLC |
19116 |
47.6‰ |
| BANK OF AMERICA CORP /DE/ |
18887 |
47.1‰ |
| ALLIANCEBERNSTEIN L.P. |
17340 |
43.2‰ |
| Raymond James Financial Services Advisors, Inc. |
17242 |
43.0‰ |
| GSA CAPITAL PARTNERS LLP |
16814 |
41.9‰ |
| Engineers Gate Manager LP |
16260 |
40.5‰ |
| DLK Investment Management, LLC |
16000 |
39.9‰ |
| JPMORGAN CHASE & CO |
15917 |
39.7‰ |
| Beacon Capital Management, LLC |
15615 |
38.9‰ |
| WELLS FARGO & COMPANY/MN |
13718 |
34.2‰ |
| VOYA INVESTMENT MANAGEMENT LLC |
12893 |
32.1‰ |
| Man Group plc |
12416 |
30.9‰ |
| MetLife Investment Management, LLC |
9729 |
24.2‰ |
| CITIGROUP INC |
8163 |
20.3‰ |
| CITADEL ADVISORS LLC |
4529 |
11.3‰ |
| BNP PARIBAS FINANCIAL MARKETS |
4113 |
10.3‰ |
| Legal & General Group Plc |
3825 |
9.5‰ |
| Ameritas Investment Partners, Inc. |
3639 |
9.1‰ |
| Steward Partners Investment Advisory, LLC |
3150 |
7.9‰ |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
2691 |
6.7‰ |
| OSAIC HOLDINGS, INC. |
2229 |
5.6‰ |
| AMALGAMATED BANK |
1285 |
3.2‰ |
| Tower Research Capital LLC (TRC) |
1040 |
2.6‰ |
| PNC FINANCIAL SERVICES GROUP, INC. |
1000 |
2.5‰ |
| nVerses Capital, LLC |
400 |
1.0‰ |
| Federation des caisses Desjardins du Quebec |
280 |
0.7‰ |
| TSFG, LLC |
100 |
0.2‰ |
| NewEdge Advisors, LLC |
17 |
< 0.1‰ |
| CWM, LLC |
9 |
< 0.1‰ |
