| WELLINGTON MANAGEMENT GROUP LLP |
8075940 |
18.8% |
| FMR LLC |
7829164 |
18.3% |
| BlackRock, Inc. |
5480670 |
12.8% |
| BlackRock Finance, Inc. |
4690761 |
10.9% |
| VANGUARD GROUP INC |
3739039 |
8.7% |
| Kynam Capital Management, LP |
3388967 |
7.9% |
| EVENTIDE ASSET MANAGEMENT, LLC |
3327132 |
7.8% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
3172399 |
7.4% |
| Polar Capital Holdings Plc |
3076783 |
7.2% |
| Bellevue Group AG |
2971615 |
6.9% |
| STATE STREET CORP |
2659088 |
6.2% |
| Point72 Asset Management, L.P. |
1937991 |
4.5% |
| GEODE CAPITAL MANAGEMENT, LLC |
1533956 |
3.6% |
| COMMODORE CAPITAL LP |
1425000 |
3.3% |
| Rock Springs Capital Management LP |
1398994 |
3.3% |
| Pictet Asset Management Holding SA |
1383680 |
3.2% |
| MARSHALL WACE, LLP |
1377868 |
3.2% |
| JENNISON ASSOCIATES LLC |
1003085 |
2.3% |
| GOLDMAN SACHS GROUP INC |
874193 |
2.0% |
| Novo Holdings A/S |
850000 |
2.0% |
| D. E. Shaw & Co., Inc. |
845560 |
2.0% |
| Woodline Partners LP |
757771 |
1.8% |
| Redmile Group, LLC |
718723 |
1.7% |
| EcoR1 Capital, LLC |
650000 |
1.5% |
| Eversept Partners, LP |
633015 |
1.5% |
| Sofinnova Investments, Inc. |
547707 |
1.3% |
| NORTHERN TRUST CORP |
545594 |
1.3% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
530443 |
1.2% |
| 5AM Venture Management, LLC |
497270 |
1.2% |
| Affinity Asset Advisors, LLC |
475400 |
1.1% |
| Nuveen Asset Management, LLC |
431880 |
1.0% |
| AMERICAN CENTURY COMPANIES INC |
416000 |
1.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC |
374910 |
0.9% |
| CITADEL ADVISORS LLC |
321212 |
0.7% |
| Candriam S.C.A. |
317509 |
0.7% |
| SPHERA FUNDS MANAGEMENT LTD. |
309265 |
0.7% |
| Laurion Capital Management LP |
290850 |
0.7% |
| TSP Capital Management Group, LLC |
249220 |
0.6% |
| BAKER BROS. ADVISORS LP |
247644 |
0.6% |
| BANK OF AMERICA CORP /DE/ |
247111 |
0.6% |
| Bank of New York Mellon Corp |
230162 |
0.5% |
| EMERALD ADVISERS, LLC |
198429 |
0.5% |
| JANE STREET GROUP, LLC |
190329 |
0.4% |
| TD ASSET MANAGEMENT INC |
189678 |
0.4% |
| NATIXIS |
165500 |
0.4% |
| MORGAN STANLEY |
163992 |
0.4% |
| UBS Group AG |
160596 |
0.4% |
| AXA S.A. |
142290 |
0.3% |
| Assenagon Asset Management S.A. |
139162 |
0.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
129787 |
0.3% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
126963 |
0.3% |
| Qube Research & Technologies Ltd |
125506 |
0.3% |
| Fisher Asset Management, LLC |
120544 |
0.3% |
| Schonfeld Strategic Advisors LLC |
119629 |
0.3% |
| Rafferty Asset Management, LLC |
119494 |
0.3% |
| PANAGORA ASSET MANAGEMENT INC |
118347 |
0.3% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
116317 |
0.3% |
| Swiss National Bank |
114300 |
0.3% |
| Mirador Capital Partners LP |
112379 |
0.3% |
| RHUMBLINE ADVISERS |
96480 |
0.2% |
| Cinctive Capital Management LP |
91127 |
0.2% |
| Crestline Management, LP |
85351 |
0.2% |
| FIRST TRUST ADVISORS LP |
77736 |
0.2% |
| ALGERT GLOBAL LLC |
75614 |
0.2% |
| Artia Global Partners LP |
75300 |
0.2% |
| PRUDENTIAL FINANCIAL INC |
72901 |
0.2% |
| ALLIANCEBERNSTEIN L.P. |
65540 |
0.2% |
| Legal & General Group Plc |
63890 |
0.1% |
| BNP PARIBAS FINANCIAL MARKETS |
62631 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
57154 |
0.1% |
| JPMORGAN CHASE & CO |
56364 |
0.1% |
| State of New Jersey Common Pension Fund D |
54350 |
0.1% |
| BARCLAYS PLC |
54174 |
0.1% |
| Atom Investors LP |
52164 |
0.1% |
| PFM Health Sciences, LP |
52120 |
0.1% |
| ALPS ADVISORS INC |
51399 |
0.1% |
| Walleye Capital LLC |
50183 |
0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
48099 |
0.1% |
| AlphaCentric Advisors LLC |
47500 |
0.1% |
| DEUTSCHE BANK AG\ |
44483 |
0.1% |
| CAPITAL FUND MANAGEMENT S.A. |
44445 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
43750 |
0.1% |
| RENAISSANCE TECHNOLOGIES LLC |
42788 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
42771 |
0.1% |
| Invesco Ltd. |
41133 |
0.1% |
| ExodusPoint Capital Management, LP |
38150 |
0.1% |
| MetLife Investment Management, LLC |
37332 |
0.1% |
| TWINBEECH CAPITAL LP |
37005 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
36770 |
0.1% |
| NEW YORK STATE COMMON RETIREMENT FUND |
29737 |
0.1% |
| NEOS Investment Management LLC |
28535 |
0.1% |
| JANUS HENDERSON GROUP PLC |
25642 |
0.1% |
| CITIGROUP INC |
25265 |
0.1% |
| DekaBank Deutsche Girozentrale |
25000 |
0.1% |
| ArrowMark Colorado Holdings LLC |
25000 |
0.1% |
| WELLS FARGO & COMPANY/MN |
22736 |
0.1% |
| PROFUND ADVISORS LLC |
22506 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
21515 |
0.1% |
| Values First Advisors, Inc. |
21319 |
49.7‰ |
| Magnetar Financial LLC |
17390 |
40.6‰ |
