| FMR LLC |
11237798 |
11.8% |
| VANGUARD GROUP INC |
9606906 |
10.1% |
| BlackRock Finance, Inc. |
6321619 |
6.6% |
| BlackRock, Inc. |
6112723 |
6.4% |
| JPMORGAN CHASE & CO |
3435232 |
3.6% |
| Avoro Capital Advisors LLC |
3000000 |
3.1% |
| Invesco Ltd. |
2937354 |
3.1% |
| Bellevue Group AG |
2471285 |
2.6% |
| NORGES BANK |
1943730 |
2.0% |
| STATE STREET CORP |
1802251 |
1.9% |
| Clearbridge Investments, LLC |
1721610 |
1.8% |
| PERCEPTIVE ADVISORS LLC |
1716407 |
1.8% |
| GEODE CAPITAL MANAGEMENT, LLC |
1686173 |
1.8% |
| FRANKLIN RESOURCES INC |
1597631 |
1.7% |
| Deep Track Capital, LP |
1537922 |
1.6% |
| Holocene Advisors, LP |
1479675 |
1.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1428410 |
1.5% |
| Alyeska Investment Group, L.P. |
1394532 |
1.5% |
| GW&K Investment Management, LLC |
1393978 |
1.5% |
| ALLIANCEBERNSTEIN L.P. |
1366467 |
1.4% |
| Pictet Asset Management Holding SA |
1255076 |
1.3% |
| WELLINGTON MANAGEMENT GROUP LLP |
1252904 |
1.3% |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
1042862 |
1.1% |
| MORGAN STANLEY |
1029869 |
1.1% |
| MACQUARIE GROUP LTD |
1011266 |
1.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
921069 |
1.0% |
| NORTHERN TRUST CORP |
897954 |
0.9% |
| MILLENNIUM MANAGEMENT LLC |
889102 |
0.9% |
| DEUTSCHE BANK AG\ |
852984 |
0.9% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
751890 |
0.8% |
| LORD, ABBETT & CO. LLC |
633458 |
0.7% |
| GOLDMAN SACHS GROUP INC |
588181 |
0.6% |
| FIRST TRUST ADVISORS LP |
583592 |
0.6% |
| D. E. Shaw & Co., Inc. |
580359 |
0.6% |
| PRINCIPAL FINANCIAL GROUP INC |
578848 |
0.6% |
| Nuveen Asset Management, LLC |
567824 |
0.6% |
| Point72 Asset Management, L.P. |
554186 |
0.6% |
| BANK OF AMERICA CORP /DE/ |
547716 |
0.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
501173 |
0.5% |
| MARSHALL WACE, LLP |
499015 |
0.5% |
| Hood River Capital Management LLC |
487518 |
0.5% |
| JANE STREET GROUP, LLC |
481205 |
0.5% |
| TimesSquare Capital Management, LLC |
411483 |
0.4% |
| BALYASNY ASSET MANAGEMENT L.P. |
406714 |
0.4% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
404656 |
0.4% |
| Avidity Partners Management LP |
400000 |
0.4% |
| EMERALD ADVISERS, LLC |
392591 |
0.4% |
| Bank of New York Mellon Corp |
349148 |
0.4% |
| First Turn Management, LLC |
347343 |
0.4% |
| BNP Paribas Asset Management Holding S.A. |
344646 |
0.4% |
| AMERIPRISE FINANCIAL INC |
343821 |
0.4% |
| Assenagon Asset Management S.A. |
342843 |
0.4% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
335319 |
0.4% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
314051 |
0.3% |
| TANG CAPITAL MANAGEMENT LLC |
300000 |
0.3% |
| BANK OF MONTREAL /CAN/ |
292975 |
0.3% |
| Qube Research & Technologies Ltd |
278574 |
0.3% |
| EAGLE ASSET MANAGEMENT INC |
271036 |
0.3% |
| AMERICAN CENTURY COMPANIES INC |
268983 |
0.3% |
| GENERAL AMERICAN INVESTORS CO INC |
261780 |
0.3% |
| Skandinaviska Enskilda Banken AB (publ) |
259121 |
0.3% |
| HRT FINANCIAL LP |
240196 |
0.3% |
| Walleye Capital LLC |
235787 |
0.2% |
| abrdn plc |
233351 |
0.2% |
| RENAISSANCE TECHNOLOGIES LLC |
222400 |
0.2% |
| Artia Global Partners LP |
216519 |
0.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
215439 |
0.2% |
| SILVERARC CAPITAL MANAGEMENT, LLC |
192345 |
0.2% |
| COMERICA BANK |
179780 |
0.2% |
| Swiss National Bank |
171600 |
0.2% |
| PINNACLE ASSOCIATES LTD |
171069 |
0.2% |
| PFM Health Sciences, LP |
170400 |
0.2% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
166516 |
0.2% |
| SEI INVESTMENTS CO |
160487 |
0.2% |
| RAYMOND JAMES & ASSOCIATES |
154527 |
0.2% |
| Nicholas Investment Partners, LP |
151409 |
0.2% |
| CANADA PENSION PLAN INVESTMENT BOARD |
146200 |
0.2% |
| Legal & General Group Plc |
145653 |
0.2% |
| Integral Health Asset Management, LLC |
145000 |
0.2% |
| Rhenman & Partners Asset Management AB |
142000 |
0.1% |
| Schonfeld Strategic Advisors LLC |
134454 |
0.1% |
| CITADEL ADVISORS LLC |
133673 |
0.1% |
| ENVESTNET ASSET MANAGEMENT INC |
126459 |
0.1% |
| RHUMBLINE ADVISERS |
125196 |
0.1% |
| PRUDENTIAL FINANCIAL INC |
121001 |
0.1% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
119570 |
0.1% |
| Privium Fund Management B.V. |
117983 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
105556 |
0.1% |
| AQR CAPITAL MANAGEMENT LLC |
105431 |
0.1% |
| Hudson Bay Capital Management LP |
105000 |
0.1% |
| DCF Advisers, LLC |
100507 |
0.1% |
| MOODY ALDRICH PARTNERS LLC |
99012 |
0.1% |
| Atika Capital Management LLC |
97500 |
0.1% |
| Neuberger Berman Group LLC |
96314 |
0.1% |
| Cubist Systematic Strategies, LLC |
95071 |
0.1% |
| Granahan Investment Management, LLC |
92585 |
0.1% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
92390 |
0.1% |
| Sonora Investment Management Group, LLC |
87430 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
86386 |
0.1% |
| NEW YORK STATE COMMON RETIREMENT FUND |
86206 |
0.1% |
