| BAKER BROS. ADVISORS LP |
10568897 |
10.1% |
| Capital International Investors |
7013568 |
6.7% |
| HHLR ADVISORS, LTD. |
5176906 |
5.0% |
| PRIMECAP MANAGEMENT CO/CA/ |
4986289 |
4.8% |
| BAILLIE GIFFORD & CO |
3681949 |
3.5% |
| Temasek Holdings (Private) Ltd |
3014171 |
2.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
2272822 |
2.2% |
| FMR LLC |
1647156 |
1.6% |
| BlackRock Finance, Inc. |
959192 |
0.9% |
| Capital International, Inc./CA/ |
855134 |
0.8% |
| BlackRock, Inc. |
733983 |
0.7% |
| Siren, L.L.C. |
653721 |
0.6% |
| Boxer Capital, LLC |
500000 |
0.5% |
| Point72 Asset Management, L.P. |
381382 |
0.4% |
| PUBLIC INVESTMENT FUND |
354385 |
0.3% |
| Artal Group S.A. |
303369 |
0.3% |
| BANK OF AMERICA CORP /DE/ |
287349 |
0.3% |
| Baird Financial Group, Inc. |
262110 |
0.3% |
| FIRST TRUST ADVISORS LP |
250351 |
0.2% |
| Artisan Partners Limited Partnership |
208418 |
0.2% |
| Capital Group Private Client Services, Inc. |
192840 |
0.2% |
| Capital International Sarl |
192425 |
0.2% |
| Soleus Capital Management, L.P. |
137700 |
0.1% |
| TD ASSET MANAGEMENT INC |
114378 |
0.1% |
| Invesco Ltd. |
111309 |
0.1% |
| Affinity Asset Advisors, LLC |
110000 |
0.1% |
| Pictet Asset Management Holding SA |
108831 |
0.1% |
| BNP PARIBAS FINANCIAL MARKETS |
103063 |
0.1% |
| BNP Paribas Asset Management Holding S.A. |
97629 |
0.1% |
| VAN ECK ASSOCIATES CORP |
95577 |
0.1% |
| EDMOND DE ROTHSCHILD HOLDING S.A. |
92890 |
0.1% |
| Legal & General Group Plc |
88860 |
0.1% |
| Connor, Clark & Lunn Investment Management Ltd. |
86876 |
0.1% |
| Mitsubishi UFJ Trust & Banking Corp |
86414 |
0.1% |
| MORGAN STANLEY |
85833 |
0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
84288 |
0.1% |
| GOLDMAN SACHS GROUP INC |
81126 |
0.1% |
| WELLS FARGO & COMPANY/MN |
80489 |
0.1% |
| CAPITAL INTERNATIONAL LTD /CA/ |
74692 |
0.1% |
| ENVESTNET ASSET MANAGEMENT INC |
63140 |
0.1% |
| AXA S.A. |
53498 |
0.1% |
| Long Corridor Asset Management Ltd |
52623 |
0.1% |
| MARSHALL WACE, LLP |
51987 |
49.8‰ |
| BARINGS LLC |
51763 |
49.6‰ |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
50262 |
48.2‰ |
| MACQUARIE GROUP LTD |
45719 |
43.8‰ |
| Woodline Partners LP |
45078 |
43.2‰ |
| GEODE CAPITAL MANAGEMENT, LLC |
37814 |
36.3‰ |
| TANG CAPITAL MANAGEMENT LLC |
37000 |
35.5‰ |
| ExodusPoint Capital Management, LP |
35275 |
33.8‰ |
| abrdn plc |
33068 |
31.7‰ |
| OPPENHEIMER ASSET MANAGEMENT INC. |
26924 |
25.8‰ |
| Handelsbanken Fonder AB |
26370 |
25.3‰ |
| Bellevue Group AG |
25629 |
24.6‰ |
| Hudson Bay Capital Management LP |
25000 |
24.0‰ |
| SEI INVESTMENTS CO |
24248 |
23.2‰ |
| HSBC HOLDINGS PLC |
24181 |
23.2‰ |
| Nan Fung Group Holdings Ltd |
23022 |
22.1‰ |
| AIA Group Ltd |
21665 |
20.8‰ |
| RAYMOND JAMES & ASSOCIATES |
21275 |
20.4‰ |
| CITIGROUP INC |
20902 |
20.0‰ |
| Erste Asset Management GmbH |
20500 |
19.7‰ |
| ASSETMARK, INC |
18608 |
17.8‰ |
| Asset Management One Co., Ltd. |
17860 |
17.1‰ |
| EFG Asset Management (North America) Corp. |
17780 |
17.0‰ |
| STIFEL FINANCIAL CORP |
17173 |
16.5‰ |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
16199 |
15.5‰ |
| JANE STREET GROUP, LLC |
16033 |
15.4‰ |
| Capital Group Investment Management Pte. Ltd. |
16030 |
15.4‰ |
| Walleye Capital LLC |
15097 |
14.5‰ |
| AlphaCentric Advisors LLC |
15000 |
14.4‰ |
| MILLENNIUM MANAGEMENT LLC |
13783 |
13.2‰ |
| GMT CAPITAL CORP |
13622 |
13.1‰ |
| DekaBank Deutsche Girozentrale |
13600 |
13.0‰ |
| JPMORGAN CHASE & CO |
12488 |
12.0‰ |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP |
12379 |
11.9‰ |
| AMERICAN CENTURY COMPANIES INC |
12297 |
11.8‰ |
| UBS Group AG |
12086 |
11.6‰ |
| NORTHERN TRUST CORP |
11760 |
11.3‰ |
| DIMENSIONAL FUND ADVISORS LP |
11499 |
11.0‰ |
| BARCLAYS PLC |
10589 |
10.2‰ |
| Colony Group, LLC |
10511 |
10.1‰ |
| JGP Global Gestao de Recursos Ltda. |
10464 |
10.0‰ |
| Old Well Partners, LLC |
10438 |
10.0‰ |
| BANK OF MONTREAL /CAN/ |
10031 |
9.6‰ |
| Exome Asset Management LLC |
10000 |
9.6‰ |
| Man Group plc |
9177 |
8.8‰ |
| Parkwood LLC |
9055 |
8.7‰ |
| KBC Group NV |
8937 |
8.6‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
8569 |
8.2‰ |
| Tower Research Capital LLC (TRC) |
8331 |
8.0‰ |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
8185 |
7.8‰ |
| Taikang Asset Management (Hong Kong) Co Ltd |
7000 |
6.7‰ |
| NEOS Investment Management LLC |
6031 |
5.8‰ |
| CITADEL ADVISORS LLC |
5780 |
5.5‰ |
| DEUTSCHE BANK AG\ |
5684 |
5.4‰ |
| Eisler Capital (US) LLC |
5657 |
5.4‰ |
| Bleakley Financial Group, LLC |
5539 |
5.3‰ |
| Simplicity Wealth,LLC |
5526 |
5.3‰ |
| Bank of New York Mellon Corp |
5299 |
5.1‰ |
