| FARALLON CAPITAL MANAGEMENT LLC |
7913123 |
10.6% |
| VANGUARD GROUP INC |
7900379 |
10.6% |
| BlackRock, Inc. |
7671939 |
10.3% |
| BlackRock Finance, Inc. |
7634379 |
10.2% |
| ARK Investment Management LLC |
7626139 |
10.2% |
| ARCH Venture Management, LLC |
5443039 |
7.3% |
| FMR LLC |
4407695 |
5.9% |
| Sumitomo Mitsui Trust Group, Inc. |
3957611 |
5.3% |
| STATE STREET CORP |
3492155 |
4.7% |
| MWG Management Ltd. |
2266934 |
3.0% |
| Nikko Asset Management Americas, Inc. |
2224415 |
3.0% |
| Temasek Holdings (Private) Ltd |
1812972 |
2.4% |
| GEODE CAPITAL MANAGEMENT, LLC |
1729581 |
2.3% |
| Redmile Group, LLC |
1703061 |
2.3% |
| FIRST TRUST ADVISORS LP |
1482271 |
2.0% |
| Bellevue Group AG |
1418121 |
1.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
1393673 |
1.9% |
| DIMENSIONAL FUND ADVISORS LP |
1049360 |
1.4% |
| DEUTSCHE BANK AG\ |
861993 |
1.2% |
| Yiheng Capital Management, L.P. |
845500 |
1.1% |
| MORGAN STANLEY |
803829 |
1.1% |
| GOLDMAN SACHS GROUP INC |
784563 |
1.1% |
| CITADEL ADVISORS LLC |
769154 |
1.0% |
| JPMORGAN CHASE & CO |
690065 |
0.9% |
| Casdin Capital, LLC |
675000 |
0.9% |
| NORTHERN TRUST CORP |
657382 |
0.9% |
| BAILLIE GIFFORD & CO |
623640 |
0.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
593266 |
0.8% |
| JANE STREET GROUP, LLC |
450216 |
0.6% |
| NORGES BANK |
410799 |
0.6% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
395920 |
0.5% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
382995 |
0.5% |
| BANK OF AMERICA CORP /DE/ |
362137 |
0.5% |
| Alphabet Inc. |
321604 |
0.4% |
| Bank of New York Mellon Corp |
287569 |
0.4% |
| TANG CAPITAL MANAGEMENT LLC |
270000 |
0.4% |
| Rock Springs Capital Management LP |
249923 |
0.3% |
| AMERIPRISE FINANCIAL INC |
230172 |
0.3% |
| Nuveen Asset Management, LLC |
184596 |
0.2% |
| TD ASSET MANAGEMENT INC |
175892 |
0.2% |
| Vestmark Advisory Solutions, Inc. |
173152 |
0.2% |
| Russell Investments Group, Ltd. |
169561 |
0.2% |
| Rafferty Asset Management, LLC |
165264 |
0.2% |
| UBS Group AG |
162577 |
0.2% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
162407 |
0.2% |
| BANK OF MONTREAL /CAN/ |
151066 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
137089 |
0.2% |
| Swiss National Bank |
136700 |
0.2% |
| RHUMBLINE ADVISERS |
132569 |
0.2% |
| TWO SIGMA INVESTMENTS, LP |
120765 |
0.2% |
| Walleye Capital LLC |
104924 |
0.1% |
| Qube Research & Technologies Ltd |
102359 |
0.1% |
| AMERICAN CENTURY COMPANIES INC |
95578 |
0.1% |
| CITIGROUP INC |
90335 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
88110 |
0.1% |
| BARCLAYS PLC |
81827 |
0.1% |
| MILLENNIUM MANAGEMENT LLC |
80844 |
0.1% |
| Liontrust Investment Partners LLP |
80000 |
0.1% |
| Legal & General Group Plc |
78373 |
0.1% |
| CAPITAL FUND MANAGEMENT S.A. |
77698 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
68295 |
0.1% |
| Invesco Ltd. |
64692 |
0.1% |
| WELLS FARGO & COMPANY/MN |
61753 |
0.1% |
| Clarius Group, LLC |
60615 |
0.1% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
59095 |
0.1% |
| Krilogy Financial LLC |
51336 |
0.1% |
| DekaBank Deutsche Girozentrale |
50000 |
0.1% |
| D.A. DAVIDSON & CO. |
49625 |
0.1% |
| TUDOR INVESTMENT CORP ET AL |
49022 |
0.1% |
| GUGGENHEIM CAPITAL LLC |
47079 |
0.1% |
| LAZARD ASSET MANAGEMENT LLC |
46916 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
46738 |
0.1% |
| Cresset Asset Management, LLC |
46648 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
44173 |
0.1% |
| MetLife Investment Management, LLC |
43534 |
0.1% |
| WELLINGTON MANAGEMENT GROUP LLP |
43108 |
0.1% |
| TWO SIGMA ADVISERS, LP |
42800 |
0.1% |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
41076 |
0.1% |
| ADAR1 Capital Management, LLC |
38312 |
0.1% |
| Hudson Bay Capital Management LP |
37500 |
0.1% |
| JANUS HENDERSON GROUP PLC |
37001 |
49.6‰ |
| Eisler Capital (US) LLC |
34378 |
46.1‰ |
| XTX Topco Ltd |
31810 |
42.6‰ |
| NEW YORK STATE COMMON RETIREMENT FUND |
31529 |
42.3‰ |
| PROFUND ADVISORS LLC |
30868 |
41.4‰ |
| Schonfeld Strategic Advisors LLC |
30517 |
40.9‰ |
| Tower Research Capital LLC (TRC) |
28363 |
38.0‰ |
| LPL Financial LLC |
26432 |
35.4‰ |
| Graham Capital Management, L.P. |
24399 |
32.7‰ |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
23870 |
32.0‰ |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
23500 |
31.5‰ |
| Scientech Research LLC |
22863 |
30.6‰ |
| Corton Capital Inc. |
21964 |
29.4‰ |
| Erste Asset Management GmbH |
21700 |
29.1‰ |
| QRG CAPITAL MANAGEMENT, INC. |
21230 |
28.4‰ |
| Zurcher Kantonalbank (Zurich Cantonalbank) |
20880 |
28.0‰ |
| FEDERATED HERMES, INC. |
20839 |
27.9‰ |
| ENVESTNET ASSET MANAGEMENT INC |
20538 |
27.5‰ |
| Arizona State Retirement System |
19431 |
26.0‰ |
| SG Americas Securities, LLC |
19142 |
25.7‰ |
