| Kohlberg Kravis Roberts & Co. L.P. |
31060971 |
19.8% |
| VIKING GLOBAL INVESTORS LP |
25120991 |
16.1% |
| VANGUARD GROUP INC |
14054748 |
9.0% |
| BlackRock, Inc. |
13709646 |
8.8% |
| BlackRock Finance, Inc. |
12448272 |
8.0% |
| Aisling Capital Management LP |
6068125 |
3.9% |
| STATE STREET CORP |
5854140 |
3.7% |
| Laurion Capital Management LP |
4388873 |
2.8% |
| JANUS HENDERSON GROUP PLC |
4312531 |
2.8% |
| Frazier Life Sciences Management, L.P. |
3632604 |
2.3% |
| GEODE CAPITAL MANAGEMENT, LLC |
3290409 |
2.1% |
| Pictet Asset Management Holding SA |
2648957 |
1.7% |
| ALLIANCEBERNSTEIN L.P. |
2452404 |
1.6% |
| GOLDMAN SACHS GROUP INC |
2298039 |
1.5% |
| Capital Research Global Investors |
2212085 |
1.4% |
| CITADEL ADVISORS LLC |
2156449 |
1.4% |
| SC US (TTGP), LTD. |
1860364 |
1.2% |
| Cormorant Asset Management, LP |
1858351 |
1.2% |
| FMR LLC |
1539913 |
1.0% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1534972 |
1.0% |
| WELLINGTON MANAGEMENT GROUP LLP |
1470110 |
0.9% |
| MORGAN STANLEY |
1429009 |
0.9% |
| HHLR ADVISORS, LTD. |
1390653 |
0.9% |
| CITIGROUP INC |
1315339 |
0.8% |
| PERCEPTIVE ADVISORS LLC |
1215346 |
0.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
1189197 |
0.8% |
| NORTHERN TRUST CORP |
1129019 |
0.7% |
| PRINCIPAL FINANCIAL GROUP INC |
1125145 |
0.7% |
| AMERICAN CENTURY COMPANIES INC |
1096734 |
0.7% |
| UBS Group AG |
1092314 |
0.7% |
| Paradigm Biocapital Advisors LP |
1089492 |
0.7% |
| Invesco Ltd. |
1088720 |
0.7% |
| Woodline Partners LP |
949570 |
0.6% |
| PRIMECAP MANAGEMENT CO/CA/ |
926900 |
0.6% |
| SPHERA FUNDS MANAGEMENT LTD. |
910070 |
0.6% |
| NORGES BANK |
893729 |
0.6% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
824818 |
0.5% |
| Prosight Management, LP |
800000 |
0.5% |
| PANAGORA ASSET MANAGEMENT INC |
727963 |
0.5% |
| JANE STREET GROUP, LLC |
717185 |
0.5% |
| EVENTIDE ASSET MANAGEMENT, LLC |
716927 |
0.5% |
| Octagon Capital Advisors LP |
690000 |
0.4% |
| ADAR1 Capital Management, LLC |
678857 |
0.4% |
| EMERALD ADVISERS, LLC |
666344 |
0.4% |
| BANK OF AMERICA CORP /DE/ |
643260 |
0.4% |
| Bank of New York Mellon Corp |
624769 |
0.4% |
| Man Group plc |
619927 |
0.4% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
609588 |
0.4% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
598263 |
0.4% |
| Nuveen Asset Management, LLC |
567681 |
0.4% |
| TWO SIGMA INVESTMENTS, LP |
565452 |
0.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
548000 |
0.4% |
| EMERALD MUTUAL FUND ADVISERS TRUST |
498254 |
0.3% |
| BARCLAYS PLC |
413265 |
0.3% |
| Caption Management, LLC |
406000 |
0.3% |
| VICTORY CAPITAL MANAGEMENT INC |
382717 |
0.2% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
353961 |
0.2% |
| TWINBEECH CAPITAL LP |
341247 |
0.2% |
| Ikarian Capital, LLC |
332013 |
0.2% |
| Board of Trustees of The Leland Stanford Junior University |
331283 |
0.2% |
| Melqart Asset Management (UK) Ltd |
307911 |
0.2% |
| DEUTSCHE BANK AG\ |
278231 |
0.2% |
| T. Rowe Price Investment Management, Inc. |
276369 |
0.2% |
| Rafferty Asset Management, LLC |
271607 |
0.2% |
| EAGLE ASSET MANAGEMENT INC |
263584 |
0.2% |
| Fernwood Investment Management, LLC |
255535 |
0.2% |
| TWO SIGMA ADVISERS, LP |
252820 |
0.2% |
| Granahan Investment Management, LLC |
251525 |
0.2% |
| Assenagon Asset Management S.A. |
246895 |
0.2% |
| Exome Asset Management LLC |
246700 |
0.2% |
| MILLENNIUM MANAGEMENT LLC |
241780 |
0.2% |
| GROUP ONE TRADING LLC |
233137 |
0.1% |
| NOMURA HOLDINGS INC |
228234 |
0.1% |
| D. E. Shaw & Co., Inc. |
224128 |
0.1% |
| RHUMBLINE ADVISERS |
221403 |
0.1% |
| Swiss National Bank |
216900 |
0.1% |
| BALYASNY ASSET MANAGEMENT L.P. |
207280 |
0.1% |
| HighTower Advisors, LLC |
201254 |
0.1% |
| 683 Capital Management, LLC |
200000 |
0.1% |
| Rhenman & Partners Asset Management AB |
184500 |
0.1% |
| WCM INVESTMENT MANAGEMENT, LLC |
176692 |
0.1% |
| JPMORGAN CHASE & CO |
176079 |
0.1% |
| Legal & General Group Plc |
168843 |
0.1% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
167839 |
0.1% |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
148368 |
0.1% |
| Erste Asset Management GmbH |
140225 |
0.1% |
| Ghost Tree Capital, LLC |
140000 |
0.1% |
| MOODY ALDRICH PARTNERS LLC |
125829 |
0.1% |
| Sio Capital Management, LLC |
125174 |
0.1% |
| AQR CAPITAL MANAGEMENT LLC |
125160 |
0.1% |
| M28 Capital Management LP |
121200 |
0.1% |
| ArrowMark Colorado Holdings LLC |
110011 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
109817 |
0.1% |
| DekaBank Deutsche Girozentrale |
100000 |
0.1% |
| Affinity Asset Advisors, LLC |
100000 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
90764 |
0.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
89994 |
0.1% |
| NEOS Investment Management LLC |
87289 |
0.1% |
| BOOTHBAY FUND MANAGEMENT, LLC |
84996 |
0.1% |
| MIZUHO MARKETS AMERICAS LLC |
83982 |
0.1% |
