| EcoR1 Capital, LLC |
6726491 |
12.6% |
| VANGUARD GROUP INC |
6671821 |
12.5% |
| BlackRock, Inc. |
6566145 |
12.3% |
| BlackRock Finance, Inc. |
6258808 |
11.8% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
3988869 |
7.5% |
| Avidity Partners Management LP |
2987845 |
5.6% |
| RTW INVESTMENTS, LP |
2967897 |
5.6% |
| FMR LLC |
2679287 |
5.0% |
| CITADEL ADVISORS LLC |
2639499 |
5.0% |
| Paradigm Biocapital Advisors LP |
2438149 |
4.6% |
| Bellevue Group AG |
2390800 |
4.5% |
| JPMORGAN CHASE & CO |
1961960 |
3.7% |
| COMMODORE CAPITAL LP |
1884361 |
3.5% |
| STATE STREET CORP |
1699688 |
3.2% |
| GEODE CAPITAL MANAGEMENT, LLC |
1541737 |
2.9% |
| Nextech Invest Ltd. |
1408394 |
2.6% |
| New Leaf Venture Partners, L.L.C. |
1289521 |
2.4% |
| ArrowMark Colorado Holdings LLC |
1226727 |
2.3% |
| NORGES BANK |
1078246 |
2.0% |
| PERCEPTIVE ADVISORS LLC |
1027749 |
1.9% |
| MORGAN STANLEY |
779791 |
1.5% |
| Candriam S.C.A. |
610458 |
1.1% |
| Boxer Capital, LLC |
608614 |
1.1% |
| GOLDMAN SACHS GROUP INC |
594425 |
1.1% |
| Finepoint Capital LP |
574378 |
1.1% |
| Opaleye Management Inc. |
555000 |
1.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
544503 |
1.0% |
| NORTHERN TRUST CORP |
495845 |
0.9% |
| DIMENSIONAL FUND ADVISORS LP |
463935 |
0.9% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
433531 |
0.8% |
| Aquilo Capital Management, LLC |
428766 |
0.8% |
| Woodline Partners LP |
423124 |
0.8% |
| RA CAPITAL MANAGEMENT, L.P. |
421348 |
0.8% |
| AMERICAN CENTURY COMPANIES INC |
325590 |
0.6% |
| BROWN ADVISORY INC |
316138 |
0.6% |
| Qube Research & Technologies Ltd |
299745 |
0.6% |
| Frazier Life Sciences Management, L.P. |
285331 |
0.5% |
| GILDER GAGNON HOWE & CO LLC |
285099 |
0.5% |
| RENAISSANCE TECHNOLOGIES LLC |
275400 |
0.5% |
| PANAGORA ASSET MANAGEMENT INC |
256658 |
0.5% |
| UBS Group AG |
256359 |
0.5% |
| Schonfeld Strategic Advisors LLC |
237724 |
0.4% |
| NORDEA INVESTMENT MANAGEMENT AB |
236174 |
0.4% |
| Bank of New York Mellon Corp |
235096 |
0.4% |
| Rhenman & Partners Asset Management AB |
230000 |
0.4% |
| D. E. Shaw & Co., Inc. |
224351 |
0.4% |
| Exome Asset Management LLC |
218700 |
0.4% |
| KENNEDY CAPITAL MANAGEMENT LLC |
212354 |
0.4% |
| Nuveen Asset Management, LLC |
202372 |
0.4% |
| MILLENNIUM MANAGEMENT LLC |
200199 |
0.4% |
| Amundi |
193665 |
0.4% |
| DEUTSCHE BANK AG\ |
186407 |
0.4% |
| TANG CAPITAL MANAGEMENT LLC |
180000 |
0.3% |
| TWO SIGMA INVESTMENTS, LP |
178326 |
0.3% |
| FEDERATED HERMES, INC. |
176352 |
0.3% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
167703 |
0.3% |
| Hudson Bay Capital Management LP |
153448 |
0.3% |
| Neuberger Berman Group LLC |
151245 |
0.3% |
| BANK OF AMERICA CORP /DE/ |
142375 |
0.3% |
| JANE STREET GROUP, LLC |
129248 |
0.2% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
108444 |
0.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
95105 |
0.2% |
| AMERIPRISE FINANCIAL INC |
94658 |
0.2% |
| Swiss National Bank |
94000 |
0.2% |
| TD ASSET MANAGEMENT INC |
91548 |
0.2% |
| Verition Fund Management LLC |
91351 |
0.2% |
| RHUMBLINE ADVISERS |
90229 |
0.2% |
| SG Americas Securities, LLC |
86096 |
0.2% |
| BANQUE PICTET & CIE SA |
82369 |
0.2% |
| WELLS FARGO & COMPANY/MN |
82058 |
0.2% |
| ZACKS INVESTMENT MANAGEMENT |
81798 |
0.2% |
| Ghost Tree Capital, LLC |
75000 |
0.1% |
| ALLIANCEBERNSTEIN L.P. |
73720 |
0.1% |
| CITIGROUP INC |
73382 |
0.1% |
| STATE OF WISCONSIN INVESTMENT BOARD |
69842 |
0.1% |
| NOMURA ASSET MANAGEMENT CO LTD |
66647 |
0.1% |
| Hennion & Walsh Asset Management, Inc. |
65907 |
0.1% |
| Legal & General Group Plc |
64901 |
0.1% |
| Graham Capital Management, L.P. |
64106 |
0.1% |
| FRANKLIN RESOURCES INC |
62024 |
0.1% |
| abrdn plc |
61492 |
0.1% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
60500 |
0.1% |
| VOYA INVESTMENT MANAGEMENT LLC |
59517 |
0.1% |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group |
57500 |
0.1% |
| Engineers Gate Manager LP |
54759 |
0.1% |
| VICTORY CAPITAL MANAGEMENT INC |
53912 |
0.1% |
| ALPS ADVISORS INC |
53365 |
0.1% |
| HighVista Strategies LLC |
51122 |
0.1% |
| Yelin Lapidot Holdings Management Ltd. |
49503 |
0.1% |
| Campbell & CO Investment Adviser LLC |
48271 |
0.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47907 |
0.1% |
| BNP PARIBAS FINANCIAL MARKETS |
44592 |
0.1% |
| ALGERT GLOBAL LLC |
44448 |
0.1% |
| Trexquant Investment LP |
44169 |
0.1% |
| DekaBank Deutsche Girozentrale |
42000 |
0.1% |
| Magnetar Financial LLC |
41992 |
0.1% |
| TWO SIGMA ADVISERS, LP |
41700 |
0.1% |
| BARCLAYS PLC |
40715 |
0.1% |
| SEVEN EIGHT CAPITAL, LP |
39239 |
0.1% |
| MetLife Investment Management, LLC |
37180 |
0.1% |
