| VANGUARD GROUP INC |
11273915 |
10.1% |
| BlackRock, Inc. |
9180463 |
8.3% |
| BlackRock Finance, Inc. |
6771456 |
6.1% |
| JPMORGAN CHASE & CO |
6065819 |
5.5% |
| FRED ALGER MANAGEMENT, LLC |
5262664 |
4.7% |
| FARALLON CAPITAL MANAGEMENT LLC |
4460557 |
4.0% |
| STATE STREET CORP |
3572796 |
3.2% |
| AMERIPRISE FINANCIAL INC |
3312966 |
3.0% |
| CITADEL ADVISORS LLC |
3047899 |
2.7% |
| Invesco Ltd. |
2605406 |
2.3% |
| RTW INVESTMENTS, LP |
2593323 |
2.3% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
2397582 |
2.2% |
| Kynam Capital Management, LP |
2014408 |
1.8% |
| Duquesne Family Office LLC |
1974880 |
1.8% |
| LORD, ABBETT & CO. LLC |
1973722 |
1.8% |
| GEODE CAPITAL MANAGEMENT, LLC |
1946655 |
1.7% |
| ALLIANCEBERNSTEIN L.P. |
1906384 |
1.7% |
| MILLENNIUM MANAGEMENT LLC |
1674165 |
1.5% |
| Sofinnova Investments, Inc. |
1550280 |
1.4% |
| SAMLYN CAPITAL, LLC |
1447946 |
1.3% |
| MORGAN STANLEY |
1435462 |
1.3% |
| AMERICAN CENTURY COMPANIES INC |
1397912 |
1.3% |
| GILDER GAGNON HOWE & CO LLC |
1383970 |
1.2% |
| NORGES BANK |
1317102 |
1.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
1220768 |
1.1% |
| Eversept Partners, LP |
1173494 |
1.1% |
| D. E. Shaw & Co., Inc. |
1145362 |
1.0% |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
1091616 |
1.0% |
| MAVERICK CAPITAL LTD |
1070339 |
1.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
1061171 |
1.0% |
| Bank of New York Mellon Corp |
1035365 |
0.9% |
| GOLDMAN SACHS GROUP INC |
1001916 |
0.9% |
| PRINCIPAL FINANCIAL GROUP INC |
983747 |
0.9% |
| Allspring Global Investments Holdings, LLC |
983312 |
0.9% |
| FMR LLC |
961427 |
0.9% |
| MARSHALL WACE, LLP |
958383 |
0.9% |
| WELLINGTON MANAGEMENT GROUP LLP |
916782 |
0.8% |
| Castle Hook Partners LP |
894585 |
0.8% |
| VOYA INVESTMENT MANAGEMENT LLC |
860740 |
0.8% |
| FRANKLIN RESOURCES INC |
770960 |
0.7% |
| FIRST TRUST ADVISORS LP |
766944 |
0.7% |
| Avidity Partners Management LP |
766500 |
0.7% |
| JENNISON ASSOCIATES LLC |
756252 |
0.7% |
| Sumitomo Mitsui Trust Group, Inc. |
740837 |
0.7% |
| EAGLE ASSET MANAGEMENT INC |
724178 |
0.7% |
| ORBIMED ADVISORS LLC |
687500 |
0.6% |
| AQR CAPITAL MANAGEMENT LLC |
651523 |
0.6% |
| BANK OF AMERICA CORP /DE/ |
575211 |
0.5% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
564205 |
0.5% |
| NORTHERN TRUST CORP |
562898 |
0.5% |
| Point72 Asset Management, L.P. |
561939 |
0.5% |
| Nuveen Asset Management, LLC |
535914 |
0.5% |
| PERCEPTIVE ADVISORS LLC |
530000 |
0.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ |
528810 |
0.5% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
521634 |
0.5% |
| Nikko Asset Management Americas, Inc. |
517941 |
0.5% |
| Pictet Asset Management Holding SA |
511861 |
0.5% |
| Blue Water Life Science Advisors, LP |
503094 |
0.5% |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC |
485772 |
0.4% |
| FEDERATED HERMES, INC. |
480745 |
0.4% |
| Amundi |
477172 |
0.4% |
| Eagle Health Investments LP |
474114 |
0.4% |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
443436 |
0.4% |
| Qube Research & Technologies Ltd |
436993 |
0.4% |
| Chevy Chase Trust Holdings, LLC |
423889 |
0.4% |
| ARK Investment Management LLC |
415342 |
0.4% |
| Assenagon Asset Management S.A. |
406653 |
0.4% |
| Capital World Investors |
396421 |
0.4% |
| PointState Capital LP |
369070 |
0.3% |
| First Light Asset Management, LLC |
369068 |
0.3% |
| Holocene Advisors, LP |
359405 |
0.3% |
| SEI INVESTMENTS CO |
354856 |
0.3% |
| TWO SIGMA INVESTMENTS, LP |
331975 |
0.3% |
| C WorldWide Group Holding A/S |
330000 |
0.3% |
| LOOMIS SAYLES & CO L P |
323865 |
0.3% |
| VICTORY CAPITAL MANAGEMENT INC |
302728 |
0.3% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
299157 |
0.3% |
| Skandinaviska Enskilda Banken AB (publ) |
290104 |
0.3% |
| Artemis Investment Management LLP |
270338 |
0.2% |
| UBS Group AG |
267761 |
0.2% |
| AXA S.A. |
265120 |
0.2% |
| DIMENSIONAL FUND ADVISORS LP |
264801 |
0.2% |
| TWINBEECH CAPITAL LP |
259953 |
0.2% |
| BNP PARIBAS FINANCIAL MARKETS |
233890 |
0.2% |
| Tri Locum Partners LP |
230585 |
0.2% |
| Swiss National Bank |
225900 |
0.2% |
| TWO SIGMA ADVISERS, LP |
225400 |
0.2% |
| Man Group plc |
223739 |
0.2% |
| RENAISSANCE TECHNOLOGIES LLC |
216500 |
0.2% |
| Bellevue Group AG |
213987 |
0.2% |
| Candriam S.C.A. |
200007 |
0.2% |
| MAPLELANE CAPITAL, LLC |
195000 |
0.2% |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
194763 |
0.2% |
| ENVESTNET ASSET MANAGEMENT INC |
187438 |
0.2% |
| MACQUARIE GROUP LTD |
185018 |
0.2% |
| Legal & General Group Plc |
178614 |
0.2% |
| KORNITZER CAPITAL MANAGEMENT INC /KS |
177384 |
0.2% |
| MPM BioImpact LLC |
174811 |
0.2% |
| SEGALL BRYANT & HAMILL, LLC |
168007 |
0.2% |
| Portolan Capital Management, LLC |
166577 |
0.1% |
